Search / Trial NCT06236724

Phase II Study Assessing Efficacy and Safety of Asciminib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase.

Launched by M.D. ANDERSON CANCER CENTER · Jan 24, 2024

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Trial Information

Current as of December 31, 2024

Recruiting

Keywords

ClinConnect Summary

This clinical trial is studying a medication called asciminib to see if it can help control Chronic Myeloid Leukemia (CML) in patients who have just been diagnosed. The main goal is to learn about how effective and safe this treatment is for individuals in the early stages of the disease. The trial is currently looking for adult participants aged 18 and older who have a specific type of CML known as Ph-positive or BCR::ABL1 positive, and who have been diagnosed within the last 12 months. Participants can also have received a limited amount of previous treatments.

If you decide to participate, you will be closely monitored throughout the study to check how well the medication works and to ensure it doesn’t cause serious side effects. It's important to know that both men and women of childbearing age must use effective birth control during the study due to potential risks to a developing fetus. Overall, this trial hopes to provide valuable information about a new treatment option for people facing CML.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • Adult participants age ≥18 years.
  • • Participants must have a diagnosis of Ph-positive or BCR::ABL1 positive CML in early chronic phase (i.e., time from diagnosis ≤12 months).
  • • Participants who received prior hydroxyurea, 1 to 2 doses of cytarabine, and/or an FDA approved TKI for \<30 days are eligible.
  • • Participants with additional chromosomal abnormalities at diagnosis (early disease) and no other criteria for accelerated phase will be eligible for this study.
  • • ECOG performance status ≤2.
  • • Participants must have adequate end organ function, defined as the following: total bilirubin ≤1.5x ULN (unless secondary to Gilbert's disease, in which case should be ≤2.5x ULN), SGPT or SGOT ≤3x ULN, creatinine clearance ≥30mL/min calculated using modified Cockcroft-Gault.
  • • Ability to understand and the willingness to sign a written informed consent document.
  • * The effects of asciminib on the developing human fetus are unknown. For this reason, women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. (Refer to Pregnancy Assessment Policy MD Anderson Institutional Policy # CLN1114). This includes all female patients, between the onset of menses (as early as 8 years of age) and 55 years unless the participant presents with an applicable exclusionary factor which may be one of the following:
  • • Postmenopausal (no menses in greater than or equal to 12 consecutive months).
  • • History of hysterectomy or bilateral salpingo-oophorectomy.
  • • Ovarian failure (Follicle Stimulating Hormone and Estradiol in menopausal range, who have received Whole Pelvic Radiation Therapy).
  • • History of bilateral tubal ligation or another surgical sterilization procedure.
  • • Approved methods of birth control are as follows: Hormonal contraception (i.e. birth control pills, injection, implant, transdermal patch, vaginal ring), Intrauterine device (IUD), Tubal Ligation or hysterectomy, Participants/Partner post vasectomy, Implantable or injectable contraceptives, and condoms plus spermicide. Not engaging in sexual activity for the total duration of the trial and the drug washout period is an acceptable practice; however periodic abstinence, the rhythm method, and the withdrawal method are not acceptable methods of birth control. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately.
  • • Men treated or enrolled on this protocol must also agree to use adequate contraception prior to the study, for the duration of study participation, and 4 months after completion of asciminib administration.
  • • For participants with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated.
  • • Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. For participants with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load.
  • • Participants with treated brain metastases are eligible if follow-up brain imaging after central nervous system (CNS)-directed therapy shows no evidence of progression.
  • • Participants with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial.
  • • Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, participants should be class 2B or better.
  • Exclusion Criteria:
  • • Participants who have received more than 30 days of prior FDA approved TKI or more than 2 doses of cytarabine.
  • • Had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study.
  • • Participants who have not recovered from adverse events due to prior anti-cancer therapy (i.e., have residual toxicities \> Grade 1) with the exception of alopecia.
  • • Participants who are receiving any other investigational agents.
  • • History of allergic reactions attributed to compounds of similar chemical or biologic composition to asciminib or other agents used in study.
  • • NYHA cardiac class 3-4 heart disease
  • * Cardiac Symptoms: Participants meeting the following criteria are not eligible unless cleared by Cardiology:
  • • Uncontrolled angina within 3 months
  • • Diagnosed or suspected congenital long QT syndrome
  • • Any history of clinically significant ventricular arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes).
  • • Prolonged QTc interval on pre-entry electrocardiogram (\> 460 msec)
  • * History of significant bleeding disorder unrelated to cancer, including unless cleared by hematologist or hemato-oncologist:
  • • Diagnosed congenital bleeding disorders (e.g., von Willebrand's disease)
  • • Diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies)
  • • Participants with active, uncontrolled psychiatric disorders including psychosis, major depression, and bipolar disorders.
  • • Participants with cognitive impairment or psychiatric illness/social situations that would limit compliance with study requirements.
  • • Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial.
  • * Evidence of other clinically significant uncontrolled condition(s) including, but not limited to:
  • • Uncontrolled and/or active systemic infection (viral, bacterial or fungal)
  • • Chronic hepatitis B virus (HBV) or hepatitis C (HCV) requiring treatment and having detectable virus load. Note: participants with serologic evidence of prior vaccination to HBV (i.e. hepatitis B surface antigen negative, anti-HBs antibody positive and anti-hepatitis B core antibody negative) or positive anti-HBc antibody from intravenous immunoglobulins may participate.
  • • Pregnant women are excluded from this study because asciminib is a BCR::ABL1 TKI with the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with asciminib, breastfeeding should be discontinued if the mother is treated with asciminib. These potential risks may also apply to other agents used in this study.
  • * Participants in late chronic phase (i.e., time from diagnosis to treatment \>12 months), accelerated (except as noted in inclusion criteria 4.1) or blast phase are excluded. The definitions of CML phases are as follows:
  • • Early chronic phase: time from diagnosis to therapy ≤12 months Late chronic phase: time from diagnosis to therapy \>12 months
  • • Blastic phase: presence of 30% blasts or more in the peripheral blood or bone marrow
  • * Accelerated phase CML: presence of any of the following features:
  • • i. Peripheral or marrow blasts 15% or more ii. Peripheral or marrow basophils 20% or more iii. Thrombocytopenia \<100 x 109/L unrelated to therapy iv. Documented extramedullary blastic disease outside liver or spleen.

Trial Officials

Elias Jabbour, MD

Principal Investigator

M.D. Anderson Cancer Center

About M.D. Anderson Cancer Center

The University of Texas MD Anderson Cancer Center is a leading institution dedicated to cancer care, research, education, and prevention. As one of the world’s most respected cancer centers, MD Anderson focuses on innovative treatment approaches and groundbreaking clinical trials aimed at improving patient outcomes. With a multidisciplinary team of experts and state-of-the-art facilities, the center is committed to advancing cancer research and providing comprehensive, personalized care to patients. MD Anderson's clinical trials play a pivotal role in translating scientific discoveries into effective therapies, positioning the center at the forefront of cancer treatment and research.

Locations

Houston, Texas, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0