Longitudinal Preschool Wheeze Biomarker Study

Launched by IMPERIAL COLLEGE LONDON · Jan 24, 2024

Keywords

ClinConnect Summary

The Longitudinal Preschool Wheeze Biomarker Study is looking into better ways to help preschool children (ages 1-5) who experience wheezing, a common breathing issue that often leads to hospital visits. Currently, most of these children are treated with inhaled steroids, but this treatment only works for about 25% of them. The goal of this study is to find new, simple tests that can help doctors understand the specific causes of wheezing in each child, so they can provide more effective treatments. The researchers want to test different non-invasive methods, like skin prick tests for allergies and a lung function test, to see if they can help identify the right treatment for each child.

To be eligible for the study, children should be between 1 and 5 years old and have had more than two hospital visits for wheezing in the past year, or at least one serious hospital stay. Parents of eligible children can expect their child to undergo some simple tests during the study, which will help researchers learn more about their breathing issues and how best to treat them. This study is important because it aims to improve the care and treatment options available for young children with wheezing, ultimately helping them breathe easier.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Aim 1, 2 and 3:
• • Children aged 1-5 years
• • More than 2 hospitalisations for acute wheeze in the last year or
• • At least 1 admission requiring high dependency unit or intravenous bronchodilator therapy in the last year.
• Aim 1 only:
• • - children undergoing clinically indicated bronchoscopy, as determined by their existing medical team, as part of their standard management
• Exclusion Criteria:
• • Alternative respiratory diagnosis such as cystic fibrosis or bronchiectasis.