Preoperative Sildenafil Administration for Hepatectomy

Launched by FIRST PEOPLE'S HOSPITAL OF CHENZHOU · Jan 25, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the use of a medication called Sildenafil Citrate, commonly known as Viagra, to see if it can help reduce bleeding during liver surgery (hepatectomy). Bleeding is a common problem during this type of surgery, and the trial aims to find out if taking Sildenafil before the operation can improve safety and outcomes for patients. The researchers want to learn how this medication affects blood flow and overall surgical results for patients undergoing either open or laparoscopic liver surgery.

To be eligible for this trial, participants need to be between 18 and 85 years old, scheduled for liver surgery, and have a certain level of liver function. They should also be in reasonably good health, meaning they should not have severe heart or kidney problems, and must be willing to take part in the study. If you participate, you will be closely monitored throughout the trial, and your safety will be a top priority. This study could potentially lead to new ways to manage bleeding during liver surgery and improve care for patients like you.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing hepatic resection
• • age from 18-85 years
• • Child-Pugh ≤B
• • ASA II-III
• • willing to join the trial.
• Exclusion Criteria:
• • Pregnancy or Lactation
• • Known Allergy to any Medications used in the Study
• • Hemoglobin (Hb) \< 90 g/L
• • Body Mass Index (BMI) \> 35 kg/m2 or \< 18 kg/m2
• • Hypertension \> 180 mmHg
• • Renal Impairment (Creatinine, Cr 178 µmol/L)
• • Severe Cardiovascular Diseases including Active Coronary Artery Disease, Severe Valve Stenosis and Hypertrophic Obstructive Cardiomyopathy, History of Stroke Within Six Months.