Early Genetic Identification of Obesity

Launched by ROLFS CONSULTING UND VERWALTUNGS-GMBH (RCV) · Jan 25, 2024

Keywords

ClinConnect Summary

The Early Genetic Identification of Obesity trial, also known as WEGIO, is studying how genetics can help identify people at risk for obesity, particularly those with specific genetic conditions. The research focuses on individuals who may have a genetic form of obesity, including those diagnosed with Bardet-Biedl Syndrome, which can come with other health issues like vision problems and cognitive challenges. The study aims to understand more about these genetic links and includes about 1,000 participants initially for genetic testing and around 40 for follow-up.

To be eligible for this study, participants need to be at least 2 years old and have certain health conditions or weight history. For children aged 2 to 18, this includes having a high body weight before age 6 and symptoms like vision problems or speech delays. For adults aged 18 and over, they should have a high body mass index (BMI) and possibly a diagnosis of Bardet-Biedl Syndrome. Participants will provide consent, and if they join, they can expect to undergo genetic testing and contribute to important research that may help improve understanding and treatment of obesity linked to genetic factors.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • Informed consent is obtained from the participant/parent/legal guardian
• • The participant is 2 years of age or older
• For a participant between 2 and 18 years of age:
• • The participant has and had a body weight more than 97th percentile before the age of 6
• * The participant has one or more of the following symptoms:
• • rod/cone dystrophy, renal abnormalities, ataxia, syndactyly, polydactyly, brachydactyly, hyperphagia, cognitive impairment, speech delay, hypogonadism
• For a participant who is 18 years of age or older:
• • The participant has BMI ≥ 30 kg/m2
• • The participant had a body weight more than 97th percentile before the age of 6 years
• • The participant has rod/cone dystrophy
• • The participant is 2 or more years of age, is clinically diagnosed with Bardet-Biedl-Syndrome (BBS) or is a sibling of an individual diagnosed with BBS via the WEGIO study
• Exclusion criteria:
• • - Not fulfilling the inclusion criteria