Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement

Launched by UNIVERSITY HOSPITAL, BORDEAUX · Jan 26, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how certain brain activities are linked to movement problems in people with Parkinson's disease and epilepsy. Specifically, researchers want to understand how different patterns of brain waves behave when individuals perform simple motor tasks. They are looking to see how these patterns might change in people with Parkinson's disease, which can cause slow movements, and in people with epilepsy, which can cause sudden, uncontrolled movements.

To be eligible for this trial, participants need to be between 18 and 75 years old and meet certain conditions. For those with Parkinson's disease, they must have already had surgery to implant electrodes in a specific part of the brain. For individuals with epilepsy, they should be undergoing a special assessment for surgery and have electrodes placed in their brain. Participants will be asked to perform simple tasks while their brain activity is monitored. This research could help improve our understanding of movement disorders and lead to better treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion criteria :
• • Male or Female
• • Between 18 and 75 years of age
• • With Parkinson's disease and already operated with implantation of electrodes in the Subthalamic nucleus connected to a PERCEPT (TM) device.
• • Giving free, informed, written consent signed by the participant and the investigator Or
• • With drug-resistant epilepsy and benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG
• • With at least one electrode exploring the basal ganglia or the thalamus.
• • Able to perform the simple motor task
• • Affiliated or beneficiary of a social security scheme;
• • Giving free, informed, written consent signed by the participant and the investigator
• Exclusion criteria:
• • Be incapable of giving consent personally
• • Be subject to a legal protection measure or be placed under judicial protection;
• • Being pregnant or breastfeeding
• • Present a serious and/or decompensated somatic or psychiatric illness