Vertical Ridge Augmentation Strategies

Launched by UNIVERSITY COLLEGE, LONDON · Feb 2, 2024

Keywords

ClinConnect Summary

This clinical trial, titled "Vertical Ridge Augmentation Strategies," is studying different methods to rebuild bone in the jaw for patients who have lost bone due to conditions like injury or dental procedures. The focus is on comparing four types of barrier membranes used with a mix of natural and artificial bone materials to see which combination leads to fewer complications and better bone growth. Researchers will also look at how well the soft tissue heals around the treatment area and gather feedback from patients about their experiences.

To participate in this study, you should be partially toothless with at least 3 mm of bone loss in your jaw. You must also be able to give written consent and use effective birth control if you're of childbearing age. However, individuals with certain health issues, recent dental procedures in the area, or active oral diseases won't be eligible. If you join, you can expect to have your healing monitored closely and be part of a process that could help improve dental restoration techniques in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Partially edentulous with a ridge that shows at least 3mm vertical bone deficiency;
• • 2. Females of childbearing potential and males agree to use an effective method of contraception from the time consent is signed until treatment discontinuation.
• • 3. Females of childbearing potential have a negative pregnancy test within 7 days prior to being registered. Participants are considered not of child bearing potential if they are surgically sterile (i.e. they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal.
• • 4. Willing and able to provide written informed consent.
• Exclusion Criteria:
• • 1. Comorbidities (or regular use of medications)
• • 2. History of bone augmentation or implant placement at the area of interest
• • 3. Females who are pregnant, planning pregnancy or breastfeeding
• • 4. Regular use of analgesic or antibiotics within 1 month before entering the study
• • 5. Disclosed smoking (including electronic cigarettes) or drinking over 14 alcoholic units per week
• • 6. Active oral diseases or poor oral hygiene (defined by full mouth dental plaque scores greater than 25%)
• • 7. Suspected or documented titanium allergy or intolerance
• • 8. Concurrent and/or recent involvement in other research that is likely to interfere with the intervention within last 3 months of study enrolment