Titration of Inspired Oxygen to Decrease the Incidence of Postoperative Pulmonary Complications

Launched by SICHUAN PROVINCIAL PEOPLE'S HOSPITAL · Jan 28, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how adjusting the amount of oxygen patients receive during lung surgery might help reduce problems that can occur after the operation. Specifically, it focuses on patients undergoing thoracoscopic pulmonary resection, a type of surgery to remove part of the lung. The researchers want to see if carefully controlling the amount of oxygen given (instead of using a fixed high level) can lower the risk of postoperative pulmonary complications, which are issues that can affect the lungs after surgery and can lead to serious health problems.

To be eligible for this study, participants should be between 18 and 80 years old, in generally good health (with a body mass index between 18 and 30), and able to provide informed consent. Those with certain lung conditions, previous lung surgeries, or other serious health issues may not qualify. Participants will be randomly placed into two groups: one will have their oxygen levels carefully adjusted during surgery, while the other will receive a standard high level of oxygen. Throughout the trial, researchers will monitor participants for any complications, hospital stay duration, and overall recovery. This study aims to find a safer way to manage oxygen during lung surgery and improve outcomes for patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ① General anesthesia with left bronchial tube intubation; ② Age range from 18 to 80 years old; ③ 18 kg/m2 ≤ BMI ≤ 30 kg/m2; ④ ASA grade I to III; ⑤ Individuals willing to participate in research and sign an informed consent form.
• Exclusion Criteria:
• • ① CT scan indicates preoperative pulmonary infection, atelectasis, and pneumothorax; ② History of respiratory system diseases (COPD, bronchiectasis, pulmonary alveoli, interstitial lung disease, etc.); ③ Previous history of lung surgery; ④ First second forced expiratory volume/estimated value (FEV1%)\<60%; ⑤ PaO2\<60mmhg (1 mmhg=0.133 kpa) or PaO2/FiO2\<300mmhg or SpO2\<90% in the suction state; ⑥ History of acute upper respiratory tract infection, acute lung injury, acute respiratory distress syndrome, or respiratory failure within 3 months prior to surgery; ⑦ Combined heart failure (NYHA heart function grading ≥ 3); ⑧ Previous history of stroke and cerebral infarction; ⑨ Severe liver dysfunction (liver failure or Child Pugh score B or C) Chronic renal failure (glomerular filtration rate\<30 ml/min) Suffering from mental illness, etc., which is not suitable for the author; æ Individuals who have participated in other clinical trials as subjects within the three months prior to participating in the study The patient refused to participate in the study.