the Effects of Different Treatment Schemes on Cognitive Function of Patients With Idiopathic Membranous Nephropathy

Launched by BEIJING FRIENDSHIP HOSPITAL · Jan 29, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how different treatment plans affect the thinking and memory skills of patients with a condition called idiopathic membranous nephropathy, which is a type of kidney disease. The researchers want to understand if these treatments can help improve cognitive function, especially in patients who may have mild cognitive impairment. They will use special brain imaging technology to look at how the brain is functioning during the study.

To participate, patients should be between the ages of 65 and 74 and have nephrotic syndrome (a group of symptoms related to kidney problems) but with normal kidney function. They must have been diagnosed with idiopathic membranous nephropathy by a biopsy and should not have received hormone or immunosuppressive treatments in the last six months. Participants will undergo assessments to evaluate their cognitive abilities and may receive different treatment options. It’s important to note that people with certain medical conditions, such as serious brain issues or those who have been diagnosed with cognitive decline or dementia before, may not be eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with nephrotic syndrome and normal renal function.
• • Patients with idiopathic membranous nephropathy diagnosed by pathology.
• • not received hormone or other immunosuppressive treatment in the past six months.
• Exclusion Criteria:
• • Unable to treat patients with hormones and immunosuppression.
• • Patients with definite intracranial diseases such as previous cerebral infarction and cerebral hemorrhage;
• • Patients who have been diagnosed with cognitive decline or dementia in the past;
• • Patients with claustrophobia or have other contraindications for magnetic resonance imaging, such as pacemakers and metal foreign bodies in the body.
• • Pregnant and lactating women