Effect of HIgh-flow Therapy in Long-term Oxygen Therapy

Launched by SKANE UNIVERSITY HOSPITAL · Feb 6, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a special type of oxygen therapy called high-flow therapy (using a device called Lumis HFT) for people who are already using long-term oxygen therapy (LTOT). This trial focuses on patients with chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD) who need extra help breathing. The goal is to see if adding this high-flow therapy improves their health over one year.

To participate, you must be at least 40 years old and have been using LTOT for at least 15 hours a day for the past 28 days. You should be using an oxygen concentrator at home, and your body mass index (BMI) should be below 35. However, if you have certain conditions, like being treated with other types of breathing support or recently being hospitalized, you might not be eligible. If you join the study, you can expect regular check-ups and support to help monitor your breathing and overall health during the trial. This research could help improve treatments for people with serious breathing problems.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 40 years or older
• • Ongoing LTOT: prescribed for at least 15 hours per day; and since at least 28 days as registered in Swedevox
• • COPD or ILD as main underlying reason for LTOT
• • Oxygen concentrator as stationary oxygen source in the home including night-time
• • Body mass index (BMI) \< 35 kg/m2
• Exclusion Criteria:
• • Current or previous treatment with home HFOT
• • Current treatment with home mechanical ventilation
• • Current treatment with home CPAP
• • Hospitalized during the last 2 weeks
• • Current smoking or contact with flames
• • Self-reported average use of the LTOT \< 15h per day (24 hours)
• • PaCO2 (breathing air at rest) \> 8 kPa
• • Strong clinical suspicion of obstructive sleep apnea (OSA) or obesity-related hypoventilation syndrome (OHS) (as judged by the responsible staff)
• • Inability to participate in the study procedures (as judged by the staff)
• • Not eligible for continuing LTOT due to other reason (as judged by the staff)
• • Expected survival less than 3 months (as judged by the staff)