Reducing Heart Failure Risk in Late-Life With Physical Activity
Launched by BRIGHAM AND WOMEN'S HOSPITAL · Jan 30, 2024
Trial Information
Current as of June 26, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial, called "Reducing Heart Failure Risk in Late-Life With Physical Activity," aims to understand how regular exercise can help people with high blood pressure, especially those who aren’t currently active. Researchers want to find out which proteins in the body are linked to the benefits of a structured exercise program designed for heart health. The study will include 42 participants who will either join a 12-week exercise program or be part of a control group that does not participate in the exercise.
To be eligible for this trial, participants should have controlled high blood pressure, certain heart structure conditions, and a body mass index (BMI) under 30. They should also be inactive, meaning they don’t already exercise regularly. Throughout the study, participants will undergo various tests, including walking tests and heart function assessments, at both the beginning and end of the program. This way, researchers can compare the health outcomes of those who exercised with those who did not. Importantly, this study is not yet recruiting participants, but it seeks to contribute valuable insights into the importance of physical activity for heart health in older adults.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Hypertension (controlled on stable medication regimen)
- • Structural heart abnormality (LVH or LA enlargement)
- • LVEF \> 50%
- • Sedentary
- • BMI \<30
- Exclusion Criteria:
- • Diabetes
- • Unable to exercise
- • Supplemental oxygen use
- • Pulmonary hypertension
- • Sleep apnea
- • Regular exercise training
- • Devices that limit ability to achieve target heart rate
- • Moderate to severe valve disease
- • Recent (within 3 months) major CV event or planned procedures (within 6 months)
- • Terminal illness, life expectancy \<6 months
- • Inability or unwillingness to comply with study requirements
- • No access to smart phone/tablet
About Brigham And Women's Hospital
Brigham and Women's Hospital (BWH) is a leading academic medical center located in Boston, Massachusetts, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As an integral part of the Partners HealthCare system, BWH combines cutting-edge medical education with a focus on patient-centered care, fostering an environment that promotes groundbreaking clinical trials across various specialties. The hospital is dedicated to translating scientific discoveries into effective treatments, making significant contributions to the fields of cardiovascular medicine, oncology, and women's health, among others. With a robust infrastructure for research and a collaborative approach, BWH aims to improve patient outcomes and enhance the overall quality of healthcare.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Trial Officials
Sheila Hegde, MD
Principal Investigator
Brigham and Women's Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported