Factors Related to the Progression of Non-target Coronary Lesions

Launched by MEI GAO · Feb 7, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how certain risk factors might affect the worsening of coronary artery problems in patients who have already been diagnosed with some non-target lesions. Non-target lesions are areas in the coronary arteries that are not the main focus of treatment but could still be important in understanding heart health. The researchers want to find out if new risk factors, alongside traditional ones, can predict how these lesions may progress and lead to further heart issues. Participants will be divided into two groups based on their follow-up angiography results: one group will have shown worsening conditions, while the other group will not.

To be eligible for the study, participants must be at least 18 years old and have had at least two coronary angiography tests at the hospital, with a gap of at least 12 months between them. Their initial tests should show a narrowing of the arteries between 20% to 70%, and they should not need immediate treatment for it. People with certain heart conditions, recent heart attacks, or other significant health issues will not be included. While the study is not yet recruiting participants, those who join can expect to contribute valuable information that may help improve understanding and treatment of coronary artery disease in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age \> 18 years old;
• • 2. Participants underwent at least two coronary angiography examinations in our hospital, and the time interval between the two angiography examinations was ≥12 months;
• • 3. At the first angiography, there is 20% to 70% stenosis in the coronary artery lesion, and no indication or condition for intervention.
• Exclusion Criteria:
• • 1. Participants had a documented medical history of various heart diseases, including congenital heart disease, pulmonary heart disease, valvular disease, cardiomyopathy, etc.
• • 2. Angiography or serum collection was conducted within 7 days following the onset of acute myocardial infarction.
• • 3. Exclusion criteria included uncontrolled severe arrhythmia and severe hepatic and renal dysfunction.
• • 4. Patients with tumor or other autoimmune diseases were excluded from the study.
• • 5. Incomplete clinical information, biochemical test information, coronary angiography data, and imaging data were considered as exclusion factors.