Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section (INPEACE)

Launched by HASSAN II UNIVERSITY · Feb 7, 2024

Keywords

ClinConnect Summary

This clinical trial, called INPEACE, is looking at two different medications—norepinephrine and phenylephrine—to see how well they help maintain blood pressure during spinal anesthesia for women having a scheduled cesarean section. The researchers want to find out if these medications affect the health of both the mothers and their newborns differently when given through a continuous infusion during the procedure.

To participate in this study, women must be healthy, full-term, and pregnant with only one baby, and they should be scheduled for an elective cesarean delivery under spinal anesthesia. They should have a stable blood pressure before the procedure. Women with certain medical conditions, like high blood pressure or other serious health issues, will not be eligible. Participants will receive either norepinephrine or phenylephrine through an IV, and the amount given will be adjusted based on their blood pressure during the surgery. This study is currently recruiting participants, and it aims to provide important information on the best ways to manage blood pressure during cesarean deliveries.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Full-term, singleton, pregnant women, nonlaboring.
• • Scheduled for elective cesarean delivery under spinal anesthesia,
• • American Society of Anesthesiologists physical status : 1 or 2
• • Baseline systolic BP between 90 and 140 mm Hg.
• Exclusion Criteria:
• • Known fetal abnormality.
• • Preexisting or pregnancy-induced hypertension, cardiovascular, cerebrovascular or kidney disease.
• • Contraindication to spinal anesthesia.
• • Peripartum hemorrhage.
• • Body mass index above 40 kg/m2.