Naloxone for Opioid Associated Out of Hospital Cardiac Arrest

Launched by UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · Feb 8, 2024

Keywords

ClinConnect Summary

This clinical trial, called NOPACA, is studying the use of naloxone, a medication that can reverse opioid overdoses, in patients who have experienced a cardiac arrest outside of a hospital. The researchers want to find out if giving naloxone early after the heart has stopped can improve survival and recovery rates compared to a placebo (a harmless substance with no active medication). They will be looking at patients who are at high risk for cardiac arrest related to opioid use and will conduct a pilot study to see how many participants they can enroll and how well the treatment works.

To be eligible for the trial, participants must be adults aged 18 and older who have experienced a cardiac arrest and have received initial emergency treatments, such as chest compressions. However, those who have already received naloxone from emergency medical services during the same event, or whose cardiac arrest was caused by trauma or drowning, will not be included. Participants in the trial can expect to be randomly assigned to receive either naloxone or a placebo, and their recovery will be monitored over time. This trial is still in the planning stages and has not started recruiting participants yet.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Patients will be eligible if all the following criteria are met:
• • • Adults (age ≥ 18 years) in OHCA per EMS protocol. ACLS interventions have been initiated by EMS: chest compressions, ventilation; • 1st dose of epinephrine given via IV or IO.
• • •. At risk of OA-OHCA (EMS presumed drug-related OHCA or NACARDI positive for occult OA-OHCA) as described above.
• Exclusion Criteria:
• • EMS plans to administer naloxone, or administration of naloxone by EMS during the same encounter
• • Cardiac arrest apparently caused by trauma, choking, or drowning.
• • Known or apparent pregnancy
• • Patient experiences ROSC prior to study drug administration
• • Prior inclusion in the study
• • Patient has an opt out bracelet or family member states exclusion •. Children less than 18 years old