Causal Role of Top-Down Theta Oscillations in Prioritization
Launched by UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL · Feb 1, 2024
Trial Information
Current as of September 10, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
The aim of this study is to investigate the causal role of functional interactions between frontal-theta dependent selection processes and posterior-alpha dependent suppression processes in the context of cognitive control by targeting theta and alpha oscillations in frontal and parietal cortex separately in phase one of the experiment. Theta and alpha oscillations are hypothesized to play complementary roles such that theta oscillations are excitatory (related to active processing) whereas alpha oscillations are inhibitory (related to suppression of processing).
Thus, the investigators hy...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Able to provide informed consent
- • History of medically intractable epilepsy
- • Speak and understand English
- • For the stimulation session, the participant must have electrodes in the relevant locations
- Exclusion Criteria:
- • Current diagnosis of other neurological illnesses including ischemic stroke, intracerebral hemorrhage, brain neoplasm
- • Major systemic illness
- • Severe cognitive impairment - diagnosed by clinician in neuropsychiatric evaluation
- • Severe psychiatric illness
- • Excessive use of alcohol or other substances
- • Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study
About University Of North Carolina, Chapel Hill
The University of North Carolina at Chapel Hill (UNC) is a leading research institution renowned for its commitment to advancing health and science through innovative clinical trials. With a robust infrastructure that supports multidisciplinary collaboration, UNC conducts cutting-edge research across various fields, including medicine, public health, and biomedical sciences. The university is dedicated to improving patient care and health outcomes by translating its research findings into practical applications. UNC’s clinical trials are designed to evaluate new therapies, interventions, and technologies, ensuring that they meet the highest ethical and scientific standards while fostering a culture of inclusivity and community engagement.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Chapel Hill, North Carolina, United States
Patients applied
Trial Officials
Flavio Frohlich, PhD
Principal Investigator
UNC Chapel Hill
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported