The Effects of tDCS Combined With rTMS on Post-stroke Cognitive Impairment

Launched by THE SECOND AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIVERSITY · Feb 1, 2024

Keywords

ClinConnect Summary

This clinical trial is looking for treatments to help stroke patients who are experiencing problems with thinking and memory, known as cognitive impairment. The researchers want to see if different types of brain stimulation—like tDCS, rTMS, or a combination of both—can improve cognitive function and how the brain works after a stroke. Participants in this study will receive either standard care, one of the brain stimulation treatments, or a combination of the two, and their progress will be compared.

To join the trial, participants need to be between 30 and 80 years old, have had a stroke, and be able to communicate during assessments. They should also have specific scores indicating cognitive impairment but should not have memory problems due to other diseases like Alzheimer's. The study is currently recruiting participants of all genders. Those who take part can expect to receive a treatment that may help improve their thinking and memory skills, with careful monitoring of their progress throughout the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Meet the clinical diagnostic criteria of the Expert Consensus on the Management of Cognitive Impairment after Stroke in 2021;
• • 30-80 years old, right-handed, unilateral hemiplegia;
• • Verbal expression can cooperate with the completion of the evaluation, sustained attention time is longer than 5 minutes;
• • Simple Mental State Examination Scale (MMSE) score ≤26 points; MoCA scale score \< 26 points; Memory test (RMBT) score less than 21 points;
• • patients or their family agree to sign the informed consent;
• • The Ethics Committee approved the trial.
• Exclusion Criteria:
• • Memory dysfunction caused by other diseases, such as Alzheimer's disease, lewy body dementia, pituitary tumor surgery, hypothyroidism, etc.;
• • There are contraindications of rTMS and tDCS for untreated intracranial aneurysms, severe epilepsy, intracranial metal, etc.
• • Patients with severe visual, cognitive or speech impairment who cannot cooperate with treatment;
• • The condition is not stable; Or other serious physical diseases.