Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure

Launched by TUFTS MEDICAL CENTER · Feb 1, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how heart failure can affect muscle mass in patients who are experiencing severe heart problems, specifically those in cardiogenic shock. Researchers want to see how much muscle mass patients lose during this critical time and how it relates to their recovery after getting advanced treatments like heart transplants or devices that help pump blood. By using ultrasound imaging, the study aims to provide valuable information about changes in muscle mass before and after these treatments, which could help improve patients' quality of life.

To participate in this study, you need to be over 18 years old and have a weakened heart (with a measurement called ejection fraction below 40%) along with specific signs of cardiogenic shock. This might include low blood pressure or signs of organ stress. However, if you have a history of certain muscle diseases or are on specific types of nutrition support, you may not be eligible. Participants can expect to have their muscle mass monitored during their hospital stay, which could contribute to better care for heart failure patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Over 18 years of age
• • 2. Ejection fraction \<40%
• • 3. Cardiogenic shock defined by clinical criteria (including any of: lactate \>2.5 mmol/L, systolic blood pressure \<90 mmHg, acute kidney or liver injury, or cardiac index \<2.1 on hemodynamic monitoring) plus the clinical requirement for at least one pressor, inotrope, or temporary mechanical circulatory support device (MCSD)
• Exclusion Criteria:
• • 1. History of LVAD or other durable ventricular assist device
• • 2. An identified clinical disorder associated with skeletal muscle weakness/wasting (e.g., muscular dystrophy, mitochondrial disorder, active cancer, modified Rankin score greater or equal to 4 post-stroke
• • 3. Chronic enteric and parenteral nutrition support patients
• • Intubation or prior history of heart transplantation are not exclusion criteria if the inclusion criteria are otherwise met.