Effect of NanoChitosan Impregnated Calcium Hydroxide as an Intracanal Medication on Postoperative Pain Intensity and Bacterial Load Reduction

Launched by CAIRO UNIVERSITY · Feb 2, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating the effects of a new treatment called NanoChitosan impregnated Calcium Hydroxide compared to standard Calcium Hydroxide when used as a medication inside root canals of teeth with pulp necrosis (a condition where the tooth's nerve has died). The study aims to see if this new treatment can reduce pain after the procedure and lower the number of bacteria present in the tooth. Researchers will measure pain using a simple scale and assess bacterial levels through lab techniques.

To participate in this trial, you need to be between 25 and 45 years old, in good health, and have a specific type of tooth problem (single-rooted premolar with pulp necrosis). You should also be able to understand the pain scale and give your consent to join the study. However, individuals with certain medical conditions, pregnant women, or those who have recently taken pain medications or antibiotics won't be eligible. If you choose to participate, you can expect to receive either the new treatment or the standard one and be part of a study that may help improve dental care for others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age between 25-45 years old.
• • 2. Males or females.
• • 3. Healthy patients who are categorized as I or II according to The American Society of Anesthesiologists. (ASA I or II)
• • 4. Patients' accepting to participate in the trial.
• • 5. Patients who can understand the pain scale and can sign the informed consent.
• • 6. Mandibular Single rooted premolars, having single root canal: Diagnosed clinically with pulp necrosis.
• • 7. Positive pain on percussion denoting apical periodontitis.(20)
• • 8. Slight widening in the periodontal membrane space
• • 9. Normal occlusal contact with opposing teeth
• Exclusion Criteria:
• • 1. Medically compromised patients having significant systemic disorders (ASA III or IV).
• • 2. If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively.
• • 3. Pregnant women
• • 4. Patients reporting bruxism, clenching, TMJ problems or traumatic occlusion
• • 5. Patients with two or more adjacent teeth requiring endodontic treatment.
• • 6. Teeth that require further procedural steps or multidisciplinary approach.
• • 1. Association with swelling or fistulous tract.
• • 2. Acute periapical abscess.
• • 3. Mobility Grade II or III.
• • 4. Pocket depth more than 5mm.
• • 5. Previous root canal treatment.
• • 6. Non-restorable.
• • 7. Immature root.
• • 8. Radiographic evidence of external or internal root resorption, vertical root fracture, perforation, calcification.
• • 7. Inability to perceive the given instructions.