Utilizing Carbon Dioxide for Assessing Coronary Blood Flow in Subjects With Coronary Artery Disease

Launched by INDIANA UNIVERSITY · Feb 2, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at a new way to assess blood flow in the heart using carbon dioxide for people with coronary artery disease (CAD). The study aims to determine if using carbon dioxide is safe and effective for this purpose. Participants will be adults over 18 years old who are clinically stable and have either suspected or confirmed CAD. To qualify, they should show signs of reduced blood flow to the heart (known as myocardial ischemia) or have specific results from imaging tests.

If you join this study, you will undergo tests to see how well your heart is receiving blood. However, not everyone can participate. People with certain heart conditions, those who have recently had a heart attack, or individuals with specific medical devices may be excluded. The study is not yet recruiting participants, but it’s important to note that if you are interested, you should talk to your healthcare provider about your eligibility and the details of what participation would involve.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Adults \> 18 years of age
• • 2. Clinically stable individuals with suspected or known coronary artery disease (CAD)
• • 3. The SPECT/PET study indicates at least a mild to moderate myocardial ischemia (\>5-9%) or fractional-flow-reserve (FFR) of \<0.75.
• Exclusion Criteria:
• • 1. Prior myocardial infarction by clinical history (subjects with prior coronary revascularization without myocardial infarction will not be excluded)
• • 2. Hypotension (systolic blood pressure \< 100 mmHg)
• • 3. Significant non-coronary cardiac disease (e.g., valvular abnormality, or cardiomyopathy, etc.)
• • 4. Inability to schedule the research study within 30 days of the SPECT/PET study and prior to any coronary revascularization procedure
• • 5. Inability to voluntarily increase their breathing rate if prompted to do so
• • 6. Persons with mechanically, magnetically, or electrically activated implants (such as cardiac pacemakers, neurostimulators, and infusion pumps), with ferromagnetic implants or foreign bodies (such as intracranial, aneurysm clips, shrapnel, and intraocular metal chips)
• • 7. Persons who are pregnant, nursing, or implanted with intrauterine devices (IUD's)
• • 8. Persons with a history of significant heart, lung, kidney, or liver disease
• • 9. Persons with asthma
• • 10. Persons who have abnormal cardiac rhythm and rate
• • 11. Persons unable to tolerate MRI secondary to an inability to lie supine for 60-90 minutes or severe claustrophobia
• • 12. Persons whose renal function test does not meet MRI contrast protocol requirements \[estimated Glomerular filtration rate (eGFR) \< 40 mL/min/1.73m2\]
• • 13. Persons with a known history of allergy to gadolinium-based contrast
• • 14. Enrollment in another research study.
• • 15. Inability or unwillingness to provide informed consent