Venous Excess and Lung Ultrasound During Continuous Kidney Replacement Therapy in Critically Ill Patients

Launched by CHULALONGKORN UNIVERSITY · Feb 4, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new way to manage fluid levels in critically ill patients with severe kidney failure. The researchers want to find out if using a combination of special ultrasound techniques can help doctors better understand how much fluid a patient has in their body and how to manage it while they are receiving continuous kidney replacement therapy (CKRT). This is important because having too much fluid can cause serious problems, and correctly managing fluid levels may improve patient outcomes.

To participate, patients need to be at least 18 years old, currently in the intensive care unit (ICU), and expected to start CKRT as determined by their doctor. However, individuals with certain conditions, such as severe heart issues or previous kidney transplants, will not be eligible. If someone joins the trial, they can expect to undergo additional ultrasound assessments during their treatment, which will help guide their fluid management. This study is currently recruiting participants and aims to improve care for patients experiencing acute kidney failure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Adults (≥ 18 years of age)
• • 2. Admitted to ICU
• • 3. Plan to initiate CKRT by clinician's judgement
• Exclusion Criteria:
• • 1. Refuse to participate
• • 2. Previous diagnosis of end-stage kidney disease (ESKD) currently on kidney replacement therapy
• • 3. Kidney tran splant recipient
• • 4. Receive KRT before ICU admission
• • 5. Structural kidney diseases which will interfere with intrarenal doppler ultrasound e.g. renal artery stenosis, autosomal dominant polycystic kidney disease etc.
• • 6. Patients with previously known conditions that interfere with portal doppler assessment, namely liver cirrhosis, severe tricuspid regurgitation with structural heart disease or massive ascites.
• • 7. Underlying disease process with a life expectancy less than 90 days
• • 8. Pregnancy
• • 9. Concomitant severe respiratory distress syndrome
• • 10. Expected life expectancy \<48 hours
• • 11. Receiving extracorporeal membrane oxygenation (ECMO)