Analysis of the Clinical Efficacy of Intravenous Application of Hemostatic Drugs in Improving the Clarity of Vision Under Endoscope, Perioperative Bleeding Volume and Anti-inflammatory Effect of Spinal Endoscopic Lumbar Fusion

Launched by CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE · Feb 11, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at the effectiveness of two medications, carosodiumsulfonate and desmopressin, in helping patients undergoing a specific type of spine surgery called endoscopic lumbar fusion. The main goals of the study are to see if these drugs can improve the clarity of vision for doctors during the procedure, reduce bleeding, and lessen inflammation afterwards. This trial is designed for adults between the ages of 35 and 65 who have been diagnosed with a particular spine condition called single-segment lumbar spondylolisthesis and meet other health requirements.

If you or a family member are considering participating, it's important to know that participants must be in generally good health, without serious medical conditions or a history of major back trauma or surgeries. Those who agree to join will be fully informed about the study and will need to sign a consent form. The trial is not yet recruiting participants, so there will be more information available once it starts. Overall, this study aims to improve surgical outcomes for patients with specific spine issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients, aged 35-65 years old, who were diagnosed as single-segment lumbar spondylolisthesis without spondylolysis based on imaging data and underwent endoscopic lumbar interbody fusion.
• • 2. In patients with normal platelet count, blood coagulation function.
• • 3. No history of major lumbar trauma and previous lumbar surgery.
• • 4. No allergy history, contraindications and serious adverse reactions to desmopressin and carosodiumsulfonate.
• • 5. American Society of Anesthesiologists (ASA) classification: grade 1-2
• • 6. The participants and their family members were informed of the nature of the study, understood the provisions of the study, complied well, and signed informed consent
• Exclusion Criteria:
• • 1. Patients who do not consent to participate in the trial.
• • 2. Poorly controlled hypertension with systolic blood pressure \>180 mmHg or diastolic blood pressure \>110 mmHg.
• • 3. People with mental illness, or poor compliance of patients.
• • 4. Patients with severe liver function impairment and creatinine clearance \<20ml/min.
• • 5. Patients with coagulopathy or inability to tolerate surgery.
• • 6. Patients with other lumbar spine diseases or pulmonary tuberculosis.
• • 7. ASA anesthesia level 3 or higher.
• • 8. Patients with a long history of smoking, alcohol abuse, or contraceptive drug abuse.
• • 9. Patients with serious heart disease, diabetes.
• • 10. Imaging tip is merged with other lumbar disease or accompanied by lumbar spondylolysis patients.
• • 11. Pregnant women.
• • 12. Patients with a history of major lumbar trauma or lumbar surgery.