Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery

Launched by KAROLINSKA INSTITUTET · Feb 4, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how mitral valve surgery affects heart rhythm problems, specifically in patients with a condition called arrhythmogenic mitral valve prolapse (MVP). The goal is to see if surgery improves heart rhythm issues and changes in heart tissue over six months. The researchers will enroll 90 patients who need surgery for mitral regurgitation, which is when the heart's mitral valve doesn't close properly. Both patients with arrhythmogenic MVP and those without it will be included to compare the results.

To participate, individuals must be 18 years or older and have a need for mitral valve surgery for primary mitral regurgitation. However, those with certain conditions, like secondary mitral regurgitation or severe heart disease, cannot join. Participants will undergo detailed heart scans and continuous heart monitoring before and after the surgery to help the researchers understand the surgery's impact. This study is currently recruiting participants, and it's a great opportunity for those who meet the criteria to contribute to important research in heart health.

Gender

ALL

Eligibility criteria

• • Inclusion criteria
• • Age 18 and over
• • Patients with and without (controls) arrhythmogenic MVP in need of mitral valve surgery for primary mitral regurgitation according to current standard of care
• • Exclusion criteria
• • Secondary mitral regurgitation
• • Primary mitral regurgitation not due to degenerative disease (including rheumatic disease)
• • Co-existing moderate or severe aortic valve disease
• • Congenital heart disease
• • Inherited or acquired cardiomyopathy
• • Non-incidental or symptomatic coronary artery disease
• • Uncontrolled atrial fibrillation (resting heart rate \> 100/min)
• • Pregnancy
• • Unable to undergo CMR