Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival

Launched by PEKING UNIVERSITY FIRST HOSPITAL · Feb 12, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how keeping patients at a stable temperature during major cancer surgery might help reduce confusion and improve long-term recovery. Sometimes, patients can become too cold during surgery, which can lead to a condition called postoperative delirium, where they might feel disoriented or confused after waking up. This study aims to see if better temperature management during surgery can lower the chances of this confusion and also help patients feel better in the long run.

To participate in this trial, you need to be at least 65 years old and scheduled for a major cancer surgery that will last 2 hours or longer. The trial is currently looking for participants, but certain health conditions, like having a fever before surgery or a history of specific neurological disorders, may prevent you from joining. If you qualify, you can expect to receive careful monitoring of your body temperature during your surgery, which could help improve your recovery experience. This study is important as it may help us understand how to enhance care for older patients undergoing cancer surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥65 years.
• • 2. Planned potentially curative initial cancer surgery with an expected duration of 2 hours or longer under general anesthesia.
• Exclusion Criteria:
• • 1. Preoperative fever (tympanic temperature ≥38℃).
• • 2. Known or suspected preoperative infection.
• • 3. Previous history of schizophrenia, epilepsy, Parkinson disease, myasthenia gravis, or delirium.
• • 4. Unable to communicate due to severe dementia, language barrier, or coma.
• • 5. Critically ill (Left ventricular ejection fraction \<30%, Child-Pugh grades C, requirement of renal replacement therapy, American Society of Anesthesiologists physical status\>IV, or expected survival \<24 hours).
• • 6. Scheduled surgery for breast cancer, intracranial tumors, or rare cancers.
• • 7. Planned to undergo therapeutic hypothermia.
• • 8. Body mass index \>30 kg/m2.
• • 9. Have participated in this study previously.
• • 10. Any other conditions that are considered unsuitable for study participation.