Different Exercise Modalities in the Treatment of NAFLD and Their Impact on Myokines

Launched by YEDITEPE UNIVERSITY · Feb 5, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how different types of exercise can help people with Non-Alcoholic Fatty Liver Disease (NAFLD). Over 12 weeks, participants will be assigned to different exercise routines, such as high-intensity interval training, resistance training, or a specific fat-burning exercise. The researchers want to see how these exercises affect not only the liver health of the participants but also certain proteins in the body, called myokines, that are important for fat metabolism. Additionally, the study will include motivational interviewing, which is a technique to help participants make lasting lifestyle changes.

To be eligible for this trial, participants should be between 25 and 50 years old and have been diagnosed with NAFLD. They should also use a smartphone and fall into specific health categories defined by the American Heart Association. Participants who have certain health issues, consume excessive alcohol, or have taken specific medications may not qualify. Those who join the trial can expect to engage in a structured exercise program while receiving support to help them change their lifestyle for better health. This study aims to provide valuable insights into the best exercise strategies for managing NAFLD.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Have received a diagnosis of Non-Alcoholic Fatty Liver Disease (NAFLD)
• • Age between 25 and 50 years old
• • Use of smartphone
• • Fall into category A or B according to the American Heart Association Risk Assessment Criteria
• Exclusion Criteria:
• • Viral hepatitis
• • Excessive alcohol consumption (more than 30 grams per day for men and more than 20 grams per day for women)
• • Use of specific medications: amiodarone, corticosteroids, methotrexate, tamoxifen, synthetic estrogen, valproic acid, intravenous tetracycline, and highly active antiretroviral drugs
• • Presence of accompanying chronic diseases such as Wilson's disease, hemochromatosis, and celiac disease
• • Liver storage diseases
• • Cancer
• • Cirrhosis
• • Advanced changes in liver ultrasonography evaluations, such as fibrosis
• • Presence of other chronic diseases (kidney failure, heart failure, atherosclerotic heart disease, hypertension, arrhythmia disorders)
• • BMI greater than 40 kg/m²
• • History of surgery or trauma in the last 6 months
• • Orthopedic and/or neurological impairment
• • Health problems that may hinder participation in the exercise program
• • Regular and continuous participation in sports or exercise at least 3 times a week for the past 3 years
• • Family history of coronary artery disease (coronary artery disease before the age of 45 in male first-degree relatives and other male relatives, or before the age of 65 in female first-degree relatives and other female relatives)
• • Presence of specific symptoms during medical history or physical examination: chest pain radiating to the neck, jaw, or arm, shortness of breath during rest or physical activity, dizziness, fainting, orthopnea or paroxysmal nocturnal dyspnea, ankle edema, palpitations or tachycardia, intermittent claudication, heart murmur, unexplained excessive fatigue
• • Fall into category C or D according to the American Heart Association Risk Assessment Criteria