Omission of Axillary Surgery in Breast Cancer Patients

Launched by KK WOMEN'S AND CHILDREN'S HOSPITAL · Feb 6, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at whether some women with early-stage breast cancer can safely avoid a specific surgery called axillary clearance, which removes lymph nodes under the arm. The goal is to see if these patients can instead have a less invasive procedure called sentinel lymph node biopsy (SLNB), which only checks a few key lymph nodes, without increasing the risk of cancer returning. Researchers believe that for women with certain types of breast cancer that have a low chance of spreading to the lymph nodes, skipping the axillary surgery could reduce complications and costs while still effectively managing their cancer.

To be eligible for this trial, participants should be women aged 55 or older with a single breast tumor no larger than 3 cm and no signs of lymph node involvement. They should also have specific types of tumors that are less aggressive. If participants join the study, they will be closely monitored for short-term outcomes, such as recovery times and complications, as well as long-term outcomes like the chance of cancer coming back. This research aims to personalize treatment plans, making them safer and more effective for patients.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • female patients aged \>/=55 years old
• • unifocal cancer on imaging
• • breast tumour size based on imaging of \</=3cm
• • no evidence of axillary adenopathy on imaging
• • patients with strongly positive ER and PR and negative HER2 on biopsy
• • grade 1-2 tumour on core biopsy
• • patient who opt for mastectomy
• Exclusion Criteria:
• • patients with T3/T4 or stage IV disease, patients with preoperative known N+ disease, bilateral breast cancers, patients planned for neoadjuvant chemotherapy, patients with other malignancies.