Assessment Of Serum And Tissue Levels Of Cold-Inducible RNA-Binding Protein In Patients With Lichen Planus

Launched by SOHAG UNIVERSITY · Feb 7, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a condition called lichen planus (LP), which is a long-lasting skin issue that can cause inflammation and discomfort. Researchers want to learn more about a protein called cold-inducible RNA-binding protein (CIRP) to see how its levels differ between people with LP and those who are healthy. By comparing the amounts of this protein in the blood and tissues of participants, the study aims to better understand the role of CIRP in LP, which could help improve treatment options in the future.

To join the study, participants must be between 18 and 60 years old and have been diagnosed with LP without receiving any treatments for the past three months. The trial is open to both men and women, but some individuals, such as those who are pregnant or have certain other health conditions, won't be eligible. If you participate, you can expect to provide blood and tissue samples, which will help researchers gather important information about LP and its connection to CIRP.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients from both sexes aged 18 - 60 years, having clinical and dermoscopic confirmed LP and did not receive any topical or systemic treatment in the last 3 months for LP.
• Exclusion Criteria:
• • 1 . Pregnancy and lactation. 2. Patients with any infections or sepsis. 3. Patients with any other dermatological diseases associated with increased CIRP levels (eg. psoriasis, vitiligo or alopecia areata).
• • 4. Patients with systemic illness (cardiac, renal, hepatic or respiratory), malignancy, with history of connective tissue diseases or on immunosuppressive treatment.
• • 5. Patients who received any topical or systemic treatment for LP 3 months before the study.
• • 6. Patients with oral, nail or scalp LP.