Home-based Exercise and Physical Activity Intervention After Kidney Transplantation: Impact of Exercise Intensity

Launched by KU LEUVEN · Feb 7, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how different levels of exercise can help people who have recently received a kidney transplant. The goal is to see if a home-based exercise program can improve physical fitness, heart health, gut health, and overall quality of life for these patients. Participants will be divided into three groups: one will do gentle exercises like stretching, another will engage in moderate-intensity workouts like aerobic exercises and strength training, and the third group will participate in more intense workouts. The study will also look at how well these exercises can be maintained after the initial training period.

To be eligible for this trial, participants must be adults who have recently received a kidney transplant and are generally healthy enough to exercise. However, those with serious heart issues, uncontrolled diabetes, or severe lung problems, among other criteria, will not be included. If you join the trial, you can expect to follow an exercise plan for six months with support and guidance, and you’ll be helping researchers understand the best ways to keep kidney transplant recipients active and healthy.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • De novo adult KTRs
• Exclusion Criteria:
• • Underlying heart disease, defined as aberrant CPET, unstable angina, non-revascularized lesions or life-threatening arrhythmias
• • Uncontrolled hypertension
• • Uncontrolled diabetes, defined as HbA1c ≥ 9%
• • Musculoskeletal disorders not allowing physical training on a cycle ergometer, or any other medical reasons by the physician considered to be a contraindication for moderate or high-intensity physical exercise
• • Multi-organ transplantation
• • Ongoing treatment for malignancies
• • Unable to understand Dutch
• • No access to smartphone and/or computer with internet access
• • Severe pulmonary disease defined as either forced vital capacity (FVC) \<50%, one-second value (FEV1) \<50%, or a diffusing capacity for carbon monoxide (DLCO) \<40% that excludes all serious underlying respiratory disease (pulmonary fibrosis, COPD GOLD II-IV, PAH).