Cognitive Disorders in Hereditary Spastic Paraplegia Type 4

Launched by CENTRAL HOSPITAL, NANCY, FRANCE · Feb 7, 2024

Keywords

ClinConnect Summary

This clinical trial is studying cognitive disorders in people with Hereditary Spastic Paraplegia Type 4, a genetic condition that primarily causes weakness in the legs and other movement-related issues. While many people with this condition experience physical symptoms, researchers have noticed that some also face challenges with thinking and memory. This trial aims to better understand these cognitive issues, which have been reported for many years but are not well understood.

To participate in the trial, individuals must be over 18 years old, live in the Grand Est region of France, and have a specific genetic change in the SPAST gene that is likely causing their condition. Those with other forms of dementia or unrelated cognitive disorders will not be eligible. Participants can expect to undergo various tests to assess their cognitive function, helping researchers gain valuable insights into how this condition affects thinking abilities. This study is currently looking for participants, and everyone, regardless of gender, is invited to join.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient over 18 years of age, living in the Grand Est region (France)
• • Patient with a pathogenic or probably pathogenic variant (class 4 or 5) in the SPAST gene.
• Exclusion Criteria:
• • dementia comorbidities or cognitive disorders unrelated to the pathology that may affect neuropsychological tests.