The Non-Specific Immunological Effects of Providing Oral Polio Vaccine to Seniors in Guinea-Bissau
Launched by BANDIM HEALTH PROJECT · Feb 11, 2024
Trial Information
Current as of November 08, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
This study is a randomized, double-blind trial to see if a single dose of oral polio vaccine (OPV) given to men aged 50 and older in Guinea-Bissau can have non-specific, or broader, benefits for the immune system. Researchers want to know if OPV can “train” the innate immune system (a kind of general immune readiness), lower levels of inflammatory markers in the body, and cause changes in immune cells’ genes and activity. There are two small sub-studies using blood tests to explore these immune changes one month after vaccination.
Participation is limited to men 50 or older who live in the Bandim Health Project area near Bissau, have a visible BCG scar, and have no history of adverse reactions to OPV or signs of an active infection. Participants will be randomly assigned to receive either OPV or a saline placebo (2 drops on a sugar lump) in a process kept blind to participants and some study staff. About 80 people are planned to enroll, with follow-up blood tests about a month after the dose to measure immune responses. The study is being conducted in Guinea-Bissau, with results not yet available.
Gender
MALE
Eligibility criteria
- Inclusion Criteria:
- • Male.
- • Living in a household which had a Bandim Health Project census visit conducted after 1 January 2017.
- • Age above 50.
- • Has a visible BCG scar.
- Exclusion Criteria:
- • Previous adverse events to OPV
- • Suspicion of active viral/bacterial/HIV infection.
About Bandim Health Project
The Bandim Health Project is a leading research initiative based in Guinea-Bissau, dedicated to improving public health outcomes through rigorous scientific investigation. Established in collaboration with local health authorities and international partners, the project focuses on a wide range of health issues, including disease prevention, maternal and child health, and infectious diseases. With a commitment to evidence-based practices, the Bandim Health Project conducts clinical trials and observational studies to inform healthcare policies and interventions, ultimately aiming to enhance health services and promote well-being in the region. Through its innovative research and community engagement, the project plays a crucial role in advancing global health knowledge and practices.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bissau, Guinea Bissau
Patients applied
Trial Officials
Anne Marie R Madsen, MD, PhD
Principal Investigator
Bandim Health Project
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported