The Non-Specific Immunological Effects of Providing Oral Polio Vaccine to Seniors in Guinea-Bissau
Launched by BANDIM HEALTH PROJECT · Feb 11, 2024
Trial Information
Current as of June 26, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
The aim is to study the non-specific immunological effects of providing a single dose of OPV to seniors aged 50 and above in Guinea-Bissau:
Hypotheses
1. OPV induces innate immune training (substudy A)
2. OPV is associated with reduced systemic inflammation (substudy A)
3. OPV induces epigenetic modifications of the innate immune cells (substudy B)
Setting: Bandim Health Project (BHP)'s Health and Demographic Surveillance System (HDSS) in Bissau.
Design: Individually randomized trial in BHP's study area. Participants will be randomized 1:1 to OPV or placebo. To limit the amount of blood...
Gender
MALE
Eligibility criteria
- Inclusion Criteria:
- • Male.
- • Living in a household which had a Bandim Health Project census visit conducted after 1 January 2017.
- • Age above 50.
- • Has a visible BCG scar.
- Exclusion Criteria:
- • Previous adverse events to OPV
- • Suspicion of active viral/bacterial/HIV infection.
About Bandim Health Project
The Bandim Health Project is a leading research initiative based in Guinea-Bissau, dedicated to improving public health outcomes through rigorous scientific investigation. Established in collaboration with local health authorities and international partners, the project focuses on a wide range of health issues, including disease prevention, maternal and child health, and infectious diseases. With a commitment to evidence-based practices, the Bandim Health Project conducts clinical trials and observational studies to inform healthcare policies and interventions, ultimately aiming to enhance health services and promote well-being in the region. Through its innovative research and community engagement, the project plays a crucial role in advancing global health knowledge and practices.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bissau, , Guinea Bissau
Patients applied
Trial Officials
Anne Marie R Madsen, MD, PhD
Principal Investigator
Bandim Health Project
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported