Conditioned Pain Modulation in Patients With Hemophilia

Launched by INVESTIGACIÓN EN HEMOFILIA Y FISIOTERAPIA · Feb 12, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how pain is processed and managed in patients with hemophilia, particularly those who experience chronic pain in their joints due to hemophilic arthropathy. The researchers want to understand how certain factors might affect the way these patients experience pain and how pain can be modulated or changed. By examining 51 male patients from three regions in Spain, they will look at various aspects like anxiety and fear of movement, as well as physical health indicators, to identify the best ways to predict how pain modulation works in these individuals.

To be eligible for the study, participants must be adult males diagnosed with either hemophilia A or B, have specific joint health issues, and be receiving regular treatment. They should not have had any recent joint bleeding episodes or taken pain medications before the trial. Participants can expect to undergo some physical tests and answer questionnaires to help researchers gather information about their pain experiences. This study is currently recruiting participants, and it aims to improve our understanding of pain management in hemophilia, which could lead to better care and treatment options in the future.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Patients diagnosed with hemophilia A or B.
• • Patients over 18 years of age.
• • Persons with a medical diagnosis of bilateral hemophilic ankle arthropathy.
• • Patients with clinical assessment by Hemophilia Joint Health Score (\>4 points).
• • Persons with hemophilia on prophylactic treatment with FVIII / FIX coagulation concentrates or monoclonal antibodies.
• • Have signed the informed consent document.
• Exclusion Criteria:
• • Patients with neurological or cognitive alterations that prevent the comprehension of the questionnaires and physical tests.
• • Patients who have had an ankle hemarthrosis in the 6 months prior to the start of the study.
• • Patients who have taken analgesic or anti-inflammatory drugs in the 30 days prior to the study.
• • Patients who are undergoing an intervention (physiotherapeutic or orthopedic) at the time of the study.