Is the Plasma Concentration of CAPGDF15 Increased in Pregnancy? A Pilot Study

Launched by UNIVERSITY OF COPENHAGEN · Feb 12, 2024

Keywords

ClinConnect Summary

This clinical trial is looking to understand whether a small protein called CAPGDF15 increases in pregnant women, similar to a hormone called GDF15, which rises significantly during pregnancy. Researchers are interested in this because low levels of GDF15 during pregnancy have been linked to a higher risk of miscarriage. To explore this, they will conduct a small pilot study involving three healthy pregnant women in their third trimester and three healthy women who are not pregnant. By comparing the levels of CAPGDF15 in both groups, the researchers hope to gather enough information to decide if a larger study is needed.

To be eligible for this trial, participants must be healthy, fit pregnant women in their third trimester, or healthy non-pregnant women who are similar in age and weight but not taking any medications. Participants can expect to provide blood samples for testing, and the findings will help determine if CAPGDF15 behaves similarly to GDF15 during pregnancy. It’s important to note that the study is currently recruiting participants and aims to gain insights that could lead to further research in this area.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Healthy and fit pregnant women in the 3rd trimester.
• • Healthy control subjects will be matched based on age and weight and must not be taking medication.
• Exclusion Criteria:
• • Ongoing illness and/or medication intake