Efficacy of Personalized Repetitive Transcranial Magnetic Stimulation Protocol Based on Functional Reserve to Enhance Upper Limb Function in Subacute Stroke Patients

Launched by SAMSUNG MEDICAL CENTER · Feb 13, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a new type of therapy called repetitive transcranial magnetic stimulation (rTMS) to help improve upper limb function in patients who have had a stroke. Specifically, the study will look at how personalized rTMS treatments, tailored to each patient’s specific needs and abilities, compare to standard low-frequency rTMS therapies. Researchers believe that because each stroke patient has different levels of recovery potential, customizing the therapy could lead to better outcomes for improving movement.

To participate in this trial, individuals must be hospitalized stroke patients who are in the subacute phase (meaning they are between 7 days and 3 months post-stroke) and have some movement difficulties in their arms. Eligible participants should also be able to follow simple commands and have a good level of cognitive function. The study is open to adults aged 19 and older, and those who agree to take part will receive the rTMS therapy as part of their treatment. It’s important to note that individuals with certain medical conditions, such as epilepsy or significant mental health issues, may not be eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. hemiplegic stroke patients in the subacute phase (7 days to 3 months from the onset) who are currently hospitalized,
• • 2. FMA score of the upper extremity ≤42,
• • 3. adequate language and cognitive function to perform at least a 1-step obey-command,
• • 4. pre-stroke functional level of modified Rankin Scale (mRS) ≤1,
• • 5. aged ≥19 years old,
• • 6. patients willing to sign the informed consent.
• Exclusion Criteria:
• • 1. those with contraindications to rTMS, such as epilepsy, implanted metal objects in the head, or a history of craniotomy,
• • 2. those with progressive of hemodynamically unstable medical conditions,
• • 3. those with coexisting neurological conditions, such as spinal cord injury or Parkinson's disease,
• • 4. those with major psychiatric disorders, such as major depression, schizophrenia, or dementia,
• • 5. those having contraindications to conduct an MRI study,
• • 6. those who are pregnant or lactating ,
• • 7. patients who have refused to participate in this study.