Use of a Bone Substitute Material in the Surgical Therapy of Furcation Defects

Launched by GÖTEBORG UNIVERSITY · Feb 13, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at a new treatment option for people with gum disease, specifically those who have a type of problem called "furcation defects" in their molar teeth. The researchers want to find out if adding a special bone substitute material during surgery can help improve the healing of these defects compared to just cleaning the area through a procedure called open-flap debridement. In total, 200 patients who have at least one molar with a degree II furcation defect will be enrolled. They will be randomly assigned to either the standard treatment or the treatment that includes the bone substitute. The main goal is to see if the furcation area can heal properly, along with checking other factors like bleeding and overall gum health.

To be eligible for this trial, participants should have at least one molar with a furcation defect that is accessible for surgery and have certain signs of gum disease, like bleeding when probing and a deep pocket around the tooth. However, those with more severe defects, certain medical conditions, or recent antibiotic use won’t be included. Participants can expect to undergo surgery and will be monitored for healing and any side effects. This trial is currently recruiting patients of all genders between the ages of 65 and 74.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients should present with at least one surgically accessible molar (in tooth position 6 or 7) diagnosed with a single furcation defect degree II (at any aspect).
• Following initial periodontal therapy, teeth to be included should present with one site with furcation defect degree II in combination with:
• • Bleeding on probing
• • Probing pocket depth of ≥6 mm
• • Soft tissue coverage of the furcation entrance Patients should present with a full mouth plaque score ≤25%.
• Exclusion Criteria:
• • Multiple deep furcation defects (degree II - III) at the same tooth
• • Vertical attachment loss \>50% at aspects not facing the furcation defect
• • Defects presenting with apico-marginal communication
• • Intake of systemic antibiotics within 6 months
• • Systemic conditions/medication impeding surgical intervention (e.g. uncontrolled diabetes, immunosuppressive medication)