Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps

Launched by CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL (CHUM) · Feb 15, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new method to reduce the chances of large colorectal polyps returning after they have been removed. Large polyps, especially those that are flat and wide (called laterally spreading lesions), can be precursors to colorectal cancer if not completely removed. In this study, researchers are comparing two techniques for treating the area after the polyp is removed: hybrid argon plasma coagulation (h-APC) and Snare Tip Soft Coagulation (STSC). They believe that using h-APC may lower the chance of the polyp coming back and help prevent complications, like bleeding, by closing the wound properly.

To participate in this trial, you must be at least 18 years old and scheduled for a procedure to remove a large colorectal polyp. You’ll also need to provide written consent to join the study. However, individuals with certain conditions, such as inflammatory bowel disease or those in poor health, cannot participate. If you join the trial, you can expect to receive either of the two treatment methods after your polyp is removed, and your health will be monitored closely to see how well the treatment works and if there are any side effects. This research aims to improve how we treat large polyps and enhance patient safety during these procedures.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • adult ≥18 years old
• • patients undergoing EMR for a large (≥20mm) colorectal LSL
• • patients providing written and informed consent for study participation.
• Exclusion Criteria:
• • inflammatory bowel disease;
• • non-elective colonoscopy;
• • poor general health (American Society of Anesthesiologists classification \>III);
• • coagulopathy or thrombocytopenia (international normalized ratio ≥1.5 or platelets \<50 x 109/L);
• • pedunculated polyps (Paris class Ip, Isp);
• • overt signs of deep submucosal invasive cancer (JNET 3);
• • biopsy proven invasive carcinoma in a potential study polyp.
• • Pregnant women