Corticosteroids in Carpal Tunnel Syndrome. Prospective Randomised Controlled Non-inferiority Study

Launched by HOSPITAL ITALIANO DE BUENOS AIRES · Feb 14, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of two different ways to give corticosteroid treatment for mild to moderate carpal tunnel syndrome, a condition that causes pain and numbness in the hand. The researchers want to find out if an intramuscular injection (a shot in the muscle) works just as well as a local injection (a shot directly into the wrist area) for relieving symptoms. They will also look at any side effects or pain experienced at the injection site for both methods.

To participate, you need to be at least 18 years old and have a diagnosis of mild to moderate carpal tunnel syndrome, which can be confirmed through certain tests. If you join the study, you will be randomly assigned to one of the two treatment groups. Researchers will follow your progress and check your symptoms at several points over the next year. This study is currently recruiting participants, and those interested will need to sign an informed consent form to take part.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Patients aged 18 years and older
• • Clinical diagnosis of mild/moderate idiopathic Carpal Tunnel Syndrome (paresthesias in the territory of the median nerve: in fingers 1, 2, 3 and radial border of 4 of the hand, nocturnal hand pain, and Positive Tinel's test, or Positive Phalen's test, or Positive Durkan's test)
• • Diagnosis by electromyography and sensory and motor conduction velocity of mild/moderate involvement
• • Patients who have agreed to participate in the study and signed the informed consent form.
• Exclusion Criteria:
• • Cervical radiculopathy, polyneuropathy, brachial plexus pathologies, thoracic operculum syndrome
• • Systemic diseases causing secondary Carpal Tunnel Syndrome (rheumatoid arthritis, diabetes with polyneuropathy, hypothyroidism with low adherence to treatment, chronic renal disease)
• • Chronic corticosteroid therapy or regular use of non-steroidal anti-inflammatory drugs
• • Severe carpal tunnel syndrome: signs of thenar atrophy, daytime pain, sensory deficit in median nerve territory (two-point discrimination test \>10mm)
• • Previous history of wrist or distal radius fracture
• • Corticosteroid allergies
• • Pregnancy