Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation?

Launched by NOVA SOUTHEASTERN UNIVERSITY · Feb 16, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at a new type of bone graft material to help preserve the shape of the jawbone after a tooth extraction. When a tooth is removed, the bone can start to shrink, which can be a problem if you want to get dental implants later. The study will compare this new graft with a well-known and widely used grafting material to see which one works better for keeping the bone in place.

To be eligible for this trial, participants should be in good health and need to have at least one premolar or molar tooth extracted, with plans for a dental implant afterward. They should also have enough healthy gum tissue and minimal bone loss. However, individuals who smoke heavily, have certain health issues like uncontrolled diabetes or cancer, or are pregnant or breastfeeding, won't be able to participate. Those who join the trial can expect to have their bone dimensions and tissue samples studied to learn how well each graft works. Your participation could help improve future dental treatments!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients in good health
• • Require the extraction of at least one premolar or molar with future implant placement
• • Sufficient keratinized gingiva (equal or more than 2mm prior to extraction),
• • No more than 3mm of buccal bone loss
• • Flapless extraction possible
• • Full mouth plaque index of less than 25%
• Exclusion Criteria:
• • Nicotine consumption equivalent to or more than 10 cigarettes per day
• • Electronic cigarette usage
• • A history of irradiation of head and neck area
• • Immunodeficiency disease
• • Uncontrolled systemic health problems (hypertension crisis 180/120, hyperthyroidism, diabetes with HbA1c over 7, recent history of stroke, cancer) History of medications that affect bone remodeling process (bisphosphonates, RANK-L inhibitors)
• • Previous adverse reaction to the biomaterials used
• • Pregnancy/lactation, or those who are trying to become pregnant.
• • Active uncontrolled or untreated periodontal disease
• • Periapical lesions greater than 1 cm and soft tissue pathology