Oral Bisoprolol Vs IV Diltiazem in Atrial Fibrillation or Flutter With Rapid Ventricular Rate.

Launched by OMAN MEDICAL SPECIALITY BOARD · Feb 18, 2024

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ClinConnect Summary

This clinical trial is studying how effective an oral medication called Bisoprolol is compared to an intravenous medication called Diltiazem in treating patients with rapid atrial fibrillation or flutter. Atrial fibrillation and flutter are conditions where the heart beats irregularly or too quickly, which can be serious. The goal of the study is to see if giving Bisoprolol in pill form can help lower heart rates quickly and safely in an emergency department setting, especially since there isn’t a lot of evidence about its use in these situations.

To participate in this trial, you need to be at least 18 years old and have been diagnosed with atrial fibrillation or flutter that is causing a fast heart rate (more than 120 beats per minute). You also need to be stable, meaning your blood pressure is okay and you're conscious and aware. If you join the study, you’ll receive either a single dose of Bisoprolol in pill form or Diltiazem through an IV. During the study, your heart rate will be monitored closely to ensure your safety and to see how well the treatments are working. This trial is important as it could help find a more convenient way to manage these heart conditions in emergency situations.

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ALL

Eligibility criteria

• Inclusion Criteria:
• • ≥ 18 years old.
• • Atrial fibrillation (RVR) or Atrial flutter on electrocardiogram.
• • Heart rate \>120 beats/min
• • Stable patient with stable vital signs (Defined as having a SBP \>110 mmHg, oxygen saturation \> 94% on room air or with a simple face mask, a respiratory rate within normal limits, being conscious and oriented, and not having any concurrent life-threatening conditions such as myocardial infarction (MI) or Class IV heart failure).
• • Mentally competent patient who can understand and sign the consent form.
• Exclusion Criteria:
• • Acute myocardial infarction.
• • Known congenital and acquired valvular defects.
• • Pre-excitation syndromes.
• • Ventricular rate \> 220beats/min.
• • Administration of AV nodal blocking agents within the previous 24 h (beta blockers, non-dihydropyridine calcium channel blockers, digoxin and amiodarone or receiving regular maintains oral dose).
• • Allergy to either bisoprolol or diltiazem.
• • Severe hepatic and renal failure.
• • Pregnancy / breastfeeding.
• • A history of cocaine or methamphetamine use within 24 hours before arrival.
• • Known Asthmatic.