Iron-deficiency Anaemia and Its Impact on Recovery After Colorectal Cancer Surgery

Launched by ONCOLOGY INSTITUTE OF VOJVODINA · Feb 18, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how iron deficiency anaemia affects recovery after surgery for colorectal cancer. Specifically, the researchers want to find out if having low iron before surgery means that patients will have more complications and a harder time recovering afterward. They will also investigate whether certain blood tests can help detect low iron levels even before anaemia develops, which could help in treating patients earlier.

To participate in the study, patients need to be adults over 18 years old who are scheduled for major surgery to treat colorectal cancer and have a specific health status (ASA III). They should not have other types of anaemia or serious kidney issues and must consent to join the study. Participants will have blood tests done before and after their surgery to gather important health information. Overall, this trial aims to improve understanding of how iron levels can impact recovery, potentially leading to better care for patients undergoing this type of surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (˃ 18 years of age)
• • ASA III clinical status
• • Patients undergoing radical surgical treatment of colorectal cancer
• • Signed written informed consent
• Exclusion Criteria:
• • Patients undergoing palliative surgical treatment of colorectal cancer
• • Anaemic patients without iron deficiency, defined as: normal serum iron concentration, TSAT, TIBC, UIBC, and decreased HGB, HCT and RBC
• • Presence of other type of anaemia than iron deficiency anaemia (e.g. alpha- or beta-thalassemia, sickle-cell anaemia, etc.)
• • History of red blood cell transfusion in the period of 120 days prior to hospital-admission
• • Stage III, IV, or V of chronic kidney disease (creatinine clearance \< 60 mL/min)
• * Significant intraoperative bleeding, which requires transfusion of red blood cell products, calculated using the Gross-formula:
• • allowable blood loss \[mL\] = (estimated blood volume \[mL\] x (initial HGB \[g/L\] - HGB level when transfusion is required \[g/L\])) / average of initial HGB and HGB level when transfusion is required \[g/L\] The cut-off value for HGB level when transfusion is required is set to 80 g/L.