Influence of Timing of Implant Placement on Early Healing Molecular Events

Launched by QUEEN MARY UNIVERSITY OF LONDON · Feb 16, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how the timing of dental implant placement affects the healing process. Dental implants are often used to replace missing teeth, but there hasn't been much research on how placing them right after a tooth extraction (immediate placement) compares to waiting a while before placing them (delayed placement). The trial will measure certain healing markers in saliva and tissue samples at different time points after the implant is placed to see how the body responds to each method.

To participate in this study, individuals need to be at least 25 years old, in good health, and have a tooth in the front area of their mouth that needs to be removed and replaced with an implant. Participants should also have proper oral hygiene and a few natural teeth nearby. Those with certain medical conditions, smokers, or individuals who are pregnant or breastfeeding cannot join the study. If eligible, participants can expect to provide samples and have their healing monitored over a period of 30 days. This research aims to better understand the healing process after dental implants to improve future treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥25 years old
• • Good/controlled medical and psychological health
• • Good oral hygiene (FMPS≤20%)
• • Presence of a tooth in the aesthetic region (from incisor to second premolar) in need of extraction and further oral rehabilitation with a single dental implant.
• • For the IP group, the extraction socket should fulfil the following parameters, as described by the 5th ITI consensus \[46\]: intact socket wall; facial bone wall ≥1mm in thickness; no acute infection at the site; availability of bone apical and palatal to the socket to provide primary stability.
• • At least one neighbouring natural tooth.
• • A functional occlusion with a minimum of four occlusal units (i.e., pairs of occluding posterior teeth).
• • Willingness to read and sign a copy of the Informed Consent Form (ICF) after reading the Patient Information Sheet (PIS), and after the nature of the study has been fully explained and potential questions fully answered.
• Exclusion Criteria:
• • Any known systemic disease severely affecting bone metabolism (e.g., Cushing's syndrome, Crohn's disease, rheumatoid arthritis, osteoporosis or diabetes type I and uncontrolled diabetes type II).
• • Self-reported HIV or viral hepatitis.
• • Self-reported alcoholism or chronic drug abuse.
• • Smokers (including current smokers or former smokers who had quit for \< 3 months); patients reporting use of vape/e-cigarettes will also be excluded.
• • Self-reported pregnancy or lactation (this criterion is due to oral tissue changes related to pregnancy and nursing, which can affect interpretation of study results).
• • Chronic treatment (i.e., 2 weeks or more) with any medication known to affect oral status or bone metabolism (e.g., bisphosphonates, hormone replacement therapy, immunosuppressants) within 1 month before baseline visit.
• • Chronic treatment with anticoagulants (including Aspirin), corticosteroids, immunosuppressants or other medications that may influence blood coagulation/count.
• • Antibiotic or anti-inflammatory therapy during the month preceding the baseline exam.
• • Untreated caries lesions and untreated/uncontrolled periodontal disease; If patients require periodontal treatment (non-surgical and/or surgical), this will be arranged outside the study protocol and completed prior to enrolment;
• • Inadequate keratinized tissue width (\<2 mm) in the mid-buccal aspect of the area to be treated in the study.
• • Physical handicaps that would interfere with the ability to perform adequate oral hygiene in the area of implant placement.
• • Patients requiring maxillary sinus lift surgery before implant placement.
• • Self-reported bruxism.
• • Patients not willing to receive animal-derived biomaterials for GBR.
• • Patients suffering from a known psychological disorder or with limited mental capacity or language skills such that study information could not be understood, informed consent could not be obtained, or simple instructions could not be followed.
• • Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or may interfere with the interpretation of trial results and, in the judgement of the investigator, would make the subject inappropriate for entry into this trial.