Impact of Ursodeoxycholic Acid Treatment on the Gallbladder Polyp Evolution

Launched by INSTITUTO DE INVESTIGACIÓN SANITARIA DE LA FUNDACIÓN JIMÉNEZ DÍAZ · Feb 19, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a medication called ursodeoxycholic acid on gallbladder polyps, which are small growths in the gallbladder. The main goal is to find out if this treatment can help reduce the size of these polyps, potentially avoiding the need for more frequent check-ups or even surgery. The trial involves patients who have gallbladder polyps but are not candidates for surgery or have chosen not to have surgery. Participants will take ursodeoxycholic acid for at least six months as part of their usual care.

To be eligible for this study, participants should have gallbladder polyps that are less than 5 mm in size and meet specific health criteria, such as being over 60 years old or having other risk factors. Those who have already taken lower doses of this medication won’t be included. Throughout the trial, researchers will compare the changes in polyp size between those who receive the medication and those who do not, helping to understand if the treatment is effective. If you or a family member are considering this trial, it could offer valuable insights into managing gallbladder polyps.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with gallbladder polyps eligible for standard follow up (without indication for cholecystectomy or patient decline surgery or polyps \< 5mm without risk factors such as age\>60 years, primary sclerosing cholangitis, asian ethnicity, sessile polypoid lesion)
• Exclusion Criteria:
• • Patients with gallbladder polyps that received ursodeoxycolic acid doses lower than 10mg/kg/day