Efficacy of Hyaluronic Acid Injection in Knee Osteoarthritis

Launched by PHRAMONGKUTKLAO COLLEGE OF MEDICINE AND HOSPITAL · Feb 25, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of Hyaluronic acid injections on patients with knee osteoarthritis, a condition that causes pain and stiffness in the knee. The researchers want to find out if these injections can help improve pain levels, joint stiffness, and overall knee function, as well as enhance the patients' quality of life. Participants in the study will receive either Hyaluronic acid or a normal saline solution (a saltwater solution) after they have received another type of injection called glucocorticoids, which are often used to reduce inflammation.

To be eligible for this trial, participants must be diagnosed with knee osteoarthritis and experience a certain level of pain (rated 4 or higher on a scale of 0 to 10). However, individuals with cognitive issues, allergies to Hyaluronic acid, certain serious health conditions, or who are pregnant or breastfeeding will not be able to participate. If you join the trial, you will receive one of the two treatments, and researchers will monitor how well it works for your knee pain and stiffness over time. This study is currently looking for participants of all genders aged 18 and older.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All participants who had been diagnosed as knee osteoarthritis according to ACR criteria with symptom of knee pain
• • Pain visual analog scare of 4 or higher
• • Exclusion Criteria: Participants who have
• • Cognitive impairment
• • History of aller to Hyaluronic acid or its component
• • History of knee arthropathy
• • Concomitant with inflammatory arthritis
• • Serious comorbidities or bedridden status
• • Current pregnancy or lactation
• • Currently use of symptomatic slow acting drugs for osteoarthritis (SYSADOA)
• • Communication problem