CT-derived Virtual Stenting Optimize Coronary Revascularization (CT-COMPASS)

Launched by CHINA NATIONAL CENTER FOR CARDIOVASCULAR DISEASES · Feb 19, 2024

Keywords

ClinConnect Summary

The CT-COMPASS trial is studying a new method called CT-derived Virtual Stenting (CT-VS) that aims to improve heart procedures known as Percutaneous Coronary Interventions (PCI). Many patients feel better after these procedures, but some still experience chest pain or other heart problems. This trial is designed to see if using CT-VS, which simulates the effects of stents before they are placed, can lead to better results compared to the standard method of using angiograms. The goal is to determine if this new approach can help achieve optimal heart function after the PCI.

To participate in this trial, individuals must be at least 18 years old, have had a coronary CT scan within the last month, and have specific types of blockages in their heart arteries. However, people with severe heart issues, certain kidney problems, or allergies to certain contrast agents used in imaging may not qualify. Participants will undergo evaluations to see if this new technique can enhance their treatment and help reduce the chances of future heart problems. This trial is currently recruiting, and anyone interested should discuss it with their healthcare provider for more information.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • General Inclusion Criteria
• • 1. Age ≥ 18 years.
• • 2. Able to understand the trial design and provide written informed consent.
• • 3. Patients with a coronary CTA performed within 30 days.
• • CCTA Inclusion Criteria
• • 1. The CCTA angiograms amenable to CT-FFR measurement.
• • 2. At least 1 lesion of 50%-90% diameter stenosis in a coronary artery with ≥2.0mm reference vessel diameter by visual assessment.
• • 3. And this target vessel is of physiological ischemia as assessed by CT-FFR.
• • Angiographic Inclusion Criteria
• • 1. The interrogated vessel is indicated for intervention assessed by operator based on indications other than CT-FFR.
• • Exclusion Criteria
• • General Exclusion Criteria
• • 1. Cardiogenic shock or severe heart failure (NYHA ≥III or LVEF\<30%).
• • 2. Severely impaired renal function: creatinine \>150μmol/L or Cockcroft-Gault calculated GFR \<45 ml/kg/1.73 m2 (calculated with Cockcroft-Gault formula).
• • 3. Allergy to iodine-containing contrast agents which cannot be adequately premedicated.
• • CCTA Exclusion Criteria
• • 1. The CCTA angiograms deems not amenable to CT-FFR measurement.
• • 2. Patients with only 1 coronary artery lesion with DS \>90% with TIMI flow \<3.
• • 3. An interrogated vessel presented with a CTO lesion.
• • 4. All coronary arteries were not physiologically ischemic.
• • 5. Coronary lesions favor CABG treatment.
• • Angiographic Exclusion Criteria
• • 1. The interrogated vessel with only 1 coronary artery lesion with DS \>90% with TIMI flow \<3.
• • 2. Coronary lesions favor CABG treatment.