A Study of the Association Between Frailty and Acute Postoperative Pain in Elderly Thoracoscopic Surgery Patients

Launched by HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY · Feb 20, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how frailty, which is a condition that can make older adults more vulnerable to health issues, affects pain levels after thoracoscopic surgery (a minimally invasive surgery on the chest). The goal is to understand the connection between frailty and acute pain after surgery to find better ways to manage pain and improve the overall well-being and mental health of older patients undergoing this type of surgery.

To participate in this study, you must be at least 60 years old, scheduled for thoracic surgery with general anesthesia, and able to provide informed consent. You will be monitored for 48 hours after surgery, where you will have the chance to control your pain medication. However, certain conditions like drug dependence or specific digestive and metabolic disorders may make you ineligible. If you join, you can expect to help researchers learn more about how to improve pain management for older patients after surgery, which could lead to better care and recovery for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. patients undergoing thoracic surgery under general anesthesia with 48 h of postoperative patient-controlled analgesia;
• • 2. age ≥60 years;
• • 3. ASA class I-III;
• • 4. signed informed consent;
• • 5. patients undergoing thoracoscopic surgery.
• Exclusion Criteria:
• • 1. Patients who themselves refuse to participate in the study;
• • 2. Drug dependence;
• • 3. Patients who cannot cooperate with communication and have verbal communication difficulties;
• • 4. Patients who cannot assess frailty preoperatively and pain postoperatively;
• • 5. Failure to provide a compliant fecal sample at the agreed time;
• • 6. antibiotic treatment within the last month;
• • 7. intestinal dysfunction (e.g., irritable bowel syndrome, inflammatory bowel disease, chronic diarrhea, and other types of intestinal disorders);
• • 8. comorbidities of certain metabolic disorders (e.g., thyroid dysfunction, diabetes mellitus, and so on) that may affect the structure of the microbial community;