A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
Launched by ASTRAZENECA · Feb 21, 2024
Trial Information
Current as of June 27, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a new inhaler that combines three medications—budesonide, glycopyrronium, and formoterol—to see how well it works in improving heart and lung health in people with Chronic Obstructive Pulmonary Disease (COPD). The goal is to compare this new inhaler to a different one that contains two of these medications. The study is for adults aged 40 to 80 who have been diagnosed with COPD, have smoked at least a certain amount in the past, and have some heart-related health risks.
If you're considering participating, you'll need to visit the study site a few times and may also have virtual check-ins. You will be required to demonstrate how to use the inhaler correctly and be willing to adjust your current COPD treatment if needed. However, certain health conditions, like active asthma or heart disease, may prevent you from joining. Overall, this study aims to help find better treatment options for people living with COPD and related heart concerns.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. Male or female participants must be 40 to 80 years of age inclusive, at the time of signing
- • the ICF.
- • 2. Demonstrate acceptable MDI administration technique at Visit 1 (V1) and Visit 2 (V2)
- • 3. A diagnosis of COPD confirmed by a post-bronchodilator FEV1/FVC ratio \< 70%
- • at V1.
- • 4. Current or former smokers with a history of at least 10 pack-years of cigarette smoking;
- • defined as (number of cigarettes per day/20) x number of years smoked. Previous smokers are defined as those who have stopped smoking for at least 6
- • months prior to V1.
- • 5. A baseline peripheral blood eosinophil count of ≥ 100 cells/mm3 assessed at Visit 1 by
- • the central laboratory
- • 6. A CAT score of ≥ 10 at Visit 1.
- • 7. Participant must fulfill at least 1 of the 4 CV disease/risk factor criteria below \[(a), (b),
- (c), or (d)\]:
- • 1. : Established CV Disease
- 2. : Combination of CV risk factors:
- • Hypertension
- • Diabetes Mellitus
- • Chronic Kidney Disease
- • Dyslipidemia
- • Obesity
- • 3. : High risk of CV disease determined using an established CV risk assessment
- • tool.
- • 4. : CT coronary Artery Calcification
- • 8. Willing and, in the opinion of the investigator, able to adjust current COPD therapy, as
- • required by the protocol.
- • 9. Willing to visit at the study site or participate in virtual visits as required per the protocol
- • to complete all study assessments.
- 10. A female is eligible to enter and participate in the study if the female is of:
- • Non-childbearing potential: either permanently sterilized or who are post-menopausal.
- • Childbearing potential: has a negative serum pregnancy test at V1 and must use one
- • highly effective form of birth control.
- • 11. Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the ICF and in the protocol.
- Exclusion Criteria:
- • 1. Active diagnosis of asthma within the past 5 years (previous diagnosis as a child or adolescent are eligible), asthma-COPD overlap, or any other chronic respiratory disease other than COPD such as alpha-1 antitrypsin deficiency, active tuberculosis, lung fibrosis, sarcoidosis, interstitial lung disease, and pulmonary hypertension.
- • 2. End-stage renal disease requiring renal replacement therapy
- • 3. History of heart or lung transplant or actively listed for heart or lung transplant.
- • 4. Implanted left ventricular assist device or implant anticipated in \< 3 months.
- • 5. History of lung cancer and/or treatment for lung cancer within the 5 years prior to Visit 1.
- 6. Unstable or life-threatening cardiac disease - participants with any of the following at Visit 1 would be excluded:
- • 1. An MI or unstable angina in the last 8 weeks
- • 2. Unstable or life-threatening cardiac arrhythmia requiring intervention in the last 8 weeks.
- • NOTE: Any participant who experiences unstable or life-threatening cardiac disease during the run-in period will be excluded but can be rescreened 8 weeks after the resolution of the event.
- • 7. Pneumonia and/or moderate or severe COPD exacerbation that has not resolved at least 8 weeks prior to Visit 1
- • 8. Any life-threatening condition, including malignancy, with a life expectancy \< 5 years, other than CV disease or COPD, that might prevent the participant from completing the study.
- • 9. Use of maintenance ICS treatment within the past 12 months.
- • 10. Unable to abstain from protocol-defined prohibited medications
- • 11. Participation in another clinical study with a study intervention administered in the last 30 days or 5 half-lives, whichever is longer prior to Visit 1 (any other investigational product that is not identified in protocol is prohibited for use during the duration of the study).
- • 12. Participants with a known hypersensitivity to LAMA, LABA or ICS or any component of the MDI.
- • 13. Involvement in the planning and/or conduct of the study (applies to both AstraZeneca staff and/or staff at the study site).
- • 14. Judgment by the investigator that the participant should not participate in the study if the participant is unlikely to comply with study procedures, restrictions, and requirements.
- • 15. Previous randomization in the present study.
- • 16. For females only - currently pregnant (confirmed with positive pregnancy test) or breastfeeding
About Astrazeneca
AstraZeneca is a global biopharmaceutical company dedicated to the discovery, development, and commercialization of innovative medicines across various therapeutic areas, including oncology, cardiovascular, respiratory, and autoimmune diseases. With a strong commitment to scientific research and patient-centric solutions, AstraZeneca leverages cutting-edge technology and a robust pipeline to address unmet medical needs. The company collaborates with healthcare professionals, academic institutions, and other organizations to advance clinical trials and deliver transformative therapies, aiming to improve health outcomes and enhance the quality of life for patients worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Englewood, Colorado, United States
Raleigh, North Carolina, United States
Columbus, Ohio, United States
Ogden, Utah, United States
Kissimmee, Florida, United States
Shreveport, Louisiana, United States
Crystal River, Florida, United States
Fort Lauderdale, Florida, United States
Székesfehérvár, , Hungary
Varese, , Italy
Medford, Oregon, United States
Newport Beach, California, United States
Omaha, Nebraska, United States
El Paso, Texas, United States
Paris Cedex 13, , France
Los Alamitos, California, United States
Hannover, , Germany
Napoli, , Italy
Siena, , Italy
Lubin, , Poland
Krakow, , Poland
Plovdiv, , Bulgaria
Varna, , Bulgaria
Bad Ischl, , Austria
Feldbach, , Austria
Graz, , Austria
Wien, , Austria
Kingston, Ontario, Canada
Esbjerg, , Denmark
Turku, , Finland
Paris, , France
Málaga, , Spain
Huntsville, Alabama, United States
Cottingham, , United Kingdom
Phoenix, Arizona, United States
Tamarac, Florida, United States
Bydgoszcz, , Poland
Mobile, Alabama, United States
Gilbert, Arizona, United States
Mesa, Arizona, United States
Aurora, Colorado, United States
Valparaiso, Indiana, United States
Boston, Massachusetts, United States
Saint Louis, Missouri, United States
Saint Louis, Missouri, United States
Grand Island, Nebraska, United States
Philadelphia, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Anderson, South Carolina, United States
Spartanburg, South Carolina, United States
Tullahoma, Tennessee, United States
Rio De Janeiro, , Brazil
Haskovo, , Bulgaria
Pleven, , Bulgaria
Plovdiv, , Bulgaria
Praha 1, , Czechia
Hvidovre, , Denmark
Heidelberg, , Germany
Marburg, , Germany
Kalocsa, , Hungary
Szolnok, , Hungary
Pavia, , Italy
Timisoara, , Romania
Manchester, , United Kingdom
Ann Arbor, Michigan, United States
Hialeah, Florida, United States
Ormond Beach, Florida, United States
Savannah, Georgia, United States
Toledo, Ohio, United States
Mckinney, Texas, United States
Ajax, Ontario, Canada
Chattanooga, Tennessee, United States
Katy, Texas, United States
Boynton Beach, Florida, United States
Tampa, Florida, United States
Richmond, Virginia, United States
Chihuahua, , Mexico
Lakeland, Florida, United States
Gaffney, South Carolina, United States
Morgantown, West Virginia, United States
Lexington, Kentucky, United States
Bamberg, , Germany
Wermsdorf, , Germany
Athens, , Greece
Ioannina, , Greece
Thessaloniki, , Greece
Firenze, , Italy
Lørenskog, , Norway
Braunau, , Austria
Plantation, Florida, United States
Wilmington, North Carolina, United States
Lake Worth, Florida, United States
Szczecin, , Poland
Miami Lakes, Florida, United States
Greenville, North Carolina, United States
Montreal, Quebec, Canada
Manila, , Philippines
Bangkok, , Thailand
Großhansdorf, , Germany
Budapest, , Hungary
Törökbálint, , Hungary
Saskatoon, Saskatchewan, Canada
Miami, Florida, United States
Norman, Oklahoma, United States
Franklin, Tennessee, United States
Clearwater, Florida, United States
Hialeah, Florida, United States
Pembroke Pines, Florida, United States
Salisbury, North Carolina, United States
Pessac, , France
Amarillo, Texas, United States
Huntersville, North Carolina, United States
Newport News, Virginia, United States
Spokane, Washington, United States
Naples, Florida, United States
Ruse, , Bulgaria
Berlin, , Germany
Leipzig, , Germany
Chandigarh, , India
Belgrade, , Serbia
Kragujevac, , Serbia
Novi Sad, , Serbia
Kelowna, British Columbia, Canada
Fort Myers, Florida, United States
Salinas, California, United States
Paducah, Kentucky, United States
Saint Louis, Missouri, United States
Charleston, South Carolina, United States
Shanghai, , China
Moers, , Germany
München, , Germany
Sremska Kamenica, , Serbia
Liverpool, , United Kingdom
Burgas, , Bulgaria
Sofia, , Bulgaria
Frankfurt/Main, , Germany
Wroclaw, , Poland
Cluj Napoca, , Romania
Brest Cedex, , France
Firenze, , Italy
Roma, , Italy
Brooklyn, New York, United States
Thunder Bay, Ontario, Canada
Loxahatchee Groves, Florida, United States
Missoula, Montana, United States
Tucson, Arizona, United States
Sao Paulo, , Brazil
Morehead City, North Carolina, United States
Grants Pass, Oregon, United States
Modena, , Italy
Shinjuku Ku, , Japan
Cullman, Alabama, United States
Thousand Oaks, California, United States
Bradenton, Florida, United States
Boise, Idaho, United States
Southfield, Michigan, United States
Albany, New York, United States
Greensboro, North Carolina, United States
Roseburg, Oregon, United States
Sioux Falls, South Dakota, United States
Kerrville, Texas, United States
Jaipur, , India
Iloilo City, , Philippines
Taipei, , Taiwan
Bangkok, , Thailand
Lincoln, Nebraska, United States
Vejle, , Denmark
Strasbourg Cedex, , France
Buenos Aires, , Argentina
Newton, Kansas, United States
La Mesa, California, United States
Chicago, Illinois, United States
Statesville, North Carolina, United States
Newport, Pennsylvania, United States
Rapid City, South Dakota, United States
Sliven, , Bulgaria
Guelph, Ontario, Canada
Hamilton, Ontario, Canada
Siping, , China
Manizales, , Colombia
Riesa, , Germany
Słupsk, , Poland
Kosice, , Slovakia
Salt Lake City, Utah, United States
Deggingen, , Germany
Glasgow, , United Kingdom
Bayonne, , France
Aalborg, , Denmark
Inglewood, California, United States
Sandanski, , Bulgaria
Creteil, , France
Bonn, , Germany
San Diego, California, United States
New Windsor, New York, United States
Marion, Ohio, United States
Camp Hill, Pennsylvania, United States
Houston, Texas, United States
Rome, , Italy
örebro, , Sweden
Aix En Provence, , France
Pringy Cedex, , France
Reims, , France
Augsburg, , Germany
Witten, , Germany
Kingwood, Texas, United States
Lomita, California, United States
Bradenton, Florida, United States
Tarzana, California, United States
Olive Branch, Mississippi, United States
Guangzhou, , China
Veracruz, , Mexico
Sendai Shi, , Japan
San Bernardino, California, United States
Washington, District Of Columbia, United States
Buenos Aires, , Argentina
Bialystok, , Poland
Ostrava, , Czechia
Humenne, , Slovakia
Garden Grove, California, United States
Oxon Hill, Maryland, United States
Las Vegas, Nevada, United States
San Dimas, California, United States
Flint, Michigan, United States
Toms River, New Jersey, United States
Cottbus, , Germany
Thessaloniki, , Greece
Gwangju, , Korea, Republic Of
Bucharest, , Romania
Villeurbanne, , France
Genoa, , Italy
Toruń, , Poland
West Jordan, Utah, United States
Exton, Pennsylvania, United States
Athens, Alabama, United States
Saint Petersburg, Florida, United States
New York, New York, United States
Dupnitsa, , Bulgaria
Kozloduy, , Bulgaria
Yambol, , Bulgaria
Quebec, , Canada
Nanchang, , China
Xalapa, , Mexico
Katowice, , Poland
Ratchathewi, , Thailand
Vinnytsia, , Ukraine
Tucker, Georgia, United States
Victoria, Texas, United States
Rosario, , Argentina
Sao Bernardo Do Campo, , Brazil
Taiyuan, , China
La Tronche, , France
Le Coudray Cedex, , France
Kyoto Shi, , Japan
Shinjuku Ku, , Japan
Alicante, , Spain
Bursa, , Turkey
Ivano Frankivsk, , Ukraine
Ijui, , Brazil
Karlsruhe, , Germany
Edelény, , Hungary
La Palma, California, United States
Suffolk, Virginia, United States
Banning, California, United States
Santa Ana, California, United States
Lafayette, Louisiana, United States
Tulsa, Oklahoma, United States
Plano, Texas, United States
Toronto, Ontario, Canada
Brandys Nad Labem, , Czechia
Helsinki, , Finland
Kuopio, , Finland
Umeå, , Sweden
Kocaeli, , Turkey
Chesterfield, , United Kingdom
London, , United Kingdom
Panorama City, California, United States
Brest, , France
Nedlands, , Australia
Chermside, , Australia
Gyöngyös Mátraháza, , Hungary
Monroe, Louisiana, United States
Fuzhou, , China
Nanjing, , China
Xiamen, , China
Zhengzhou, , China
Sieradz, , Poland
Albuquerque, New Mexico, United States
Daegu, , Korea, Republic Of
İstanbul, , Turkey
Sacramento, California, United States
Westminster, California, United States
Hollywood, Florida, United States
Zachary, Louisiana, United States
Fremont, Nebraska, United States
Winston Salem, North Carolina, United States
Union, South Carolina, United States
Dallas, Texas, United States
St Charles Borromee, Quebec, Canada
Fairhope, Alabama, United States
Sheffield, Alabama, United States
Bradenton, Florida, United States
Cutler Bay, Florida, United States
Glen Burnie, Maryland, United States
Bountiful, Utah, United States
Ranelagh, , Argentina
São Paulo, , Brazil
Pazardzhik, , Bulgaria
Santiago, , Chile
Pingxiang, , China
Armenia, , Colombia
København Nv, , Denmark
Dresden, , Germany
Chuo Ku, , Japan
Culiacan, , Mexico
Skedsmokorset, , Norway
Chojnice, , Poland
Rzeszów, , Poland
Ustroń, , Poland
Madrid, , Spain
Taichung, , Taiwan
Hat Yai, , Thailand
Antalya, , Turkey
Granada, , Spain
Waco, Texas, United States
Cleveland, Ohio, United States
Offenbach Am Main, , Germany
Tainan City, , Taiwan
Winfield, Illinois, United States
Gödöllő, , Hungary
Százhalombatta, , Hungary
Vratsa, , Bulgaria
Talca, , Chile
Lyon Cedex 04, , France
Karczew, , Poland
Blue Ash, Ohio, United States
Quezon City, , Philippines
Glendale, Arizona, United States
Hohhot, , China
Seoul, , Korea, Republic Of
Ulsan, , Korea, Republic Of
Piaseczno, , Poland
Kyiv, , Ukraine
Van Nuys, California, United States
Port Macquarie, , Australia
Patras, , Greece
Bronxville, New York, United States
Columbia, South Carolina, United States
Austin, Texas, United States
Mcallen, Texas, United States
Sherwood Park, Alberta, Canada
Rokycany, , Czechia
Frankfurt, , Germany
Hajdúnánás, , Hungary
Pécs, , Hungary
Mizunami Shi, , Japan
Takamatsu Shi, , Japan
Yanagawa Shi, , Japan
Yokohama Shi, , Japan
Okayama Shi, , Japan
Kaohsiung, , Taiwan
Santo Andre, , Brazil
Sorocaba, , Brazil
Quillota, , Chile
Haikou, , China
Shanghai, , China
Wenzhou, , China
Monor, , Hungary
Edgewater, Florida, United States
Florencio Varela, , Argentina
Mendoza, , Argentina
Curico, , Chile
Næstved, , Denmark
Guadalajara, , Mexico
Ostrowiec świętokrzyski, , Poland
Sosnowiec, , Poland
Mersin, , Turkey
Landsberg, , Germany
Mumbai, , India
Sochaczew, , Poland
Aurillac Cedex, , France
Dobrich, , Bulgaria
Montana, , Bulgaria
Barranquilla, , Colombia
Mexico City, , Mexico
Barakaldo, , Spain
Lübeck, , Germany
Chancay, , Peru
Marbella (Málaga), , Spain
Levice, , Slovakia
Anyang Si, , Korea, Republic Of
Kansas City, Missouri, United States
Presov, , Slovakia
Paris, , France
Inowrocław, , Poland
Phitsanulok, , Thailand
Hangzhou, , China
Lima, , Peru
Bronx, New York, United States
Florida, , Argentina
Cairns, , Australia
Baotou, , China
Changsha, , China
Lanzhou, , China
Shijiazhuang, , China
Xiangtan, , China
Marseille, , France
Darmstadt, , Germany
Ibbenbüren, , Germany
Leipzig, , Germany
Peine, , Germany
Rosenheim, , Germany
Wiesbaden, , Germany
Taoyuan, , Taiwan
Corby, , United Kingdom
Porto Alegre, , Brazil
Urumqi, , China
Kayseri, , Turkey
Trois Rivières, Quebec, Canada
Zhuhai, , China
Fukuoka Shi, , Japan
Kure Shi, , Japan
Brownsville, Texas, United States
Olomouc, , Czechia
Canoga Park, California, United States
Lewisville, Texas, United States
Cuernavaca, , Mexico
Homestead, Florida, United States
Sao Bernardo Do Campo, , Brazil
Trondheim, , Norway
Dubois, Pennsylvania, United States
łódź, , Poland
Ternopil, , Ukraine
Uzhhorod, , Ukraine
Denison, Texas, United States
Lublin, , Poland
Xuzhou, , China
Anhui, , China
Yangzhou, , China
Campinas, , Brazil
Chifeng, , China
Belagavi, , India
Caxias Do Sul, , Brazil
Foshan, , China
Mangalore, , India
Panagyurishte, , Bulgaria
Lake City, Florida, United States
Püspökladány, , Hungary
Liuzhou, , China
Mexico City, , Mexico
Milwaukee, Wisconsin, United States
Rheine, , Germany
Changzhi, , China
Jining, , China
Lishui, , China
Xinxiang, , China
Yinchuan, , China
Kuala Lumpur, , Malaysia
Seremban, , Malaysia
Izmir, , Turkey
Poznań, , Poland
Cudahy, Wisconsin, United States
Spearwood, , Australia
Blumenau, , Brazil
Fujieda Shi, , Japan
Kitakyusyu, , Japan
Oklahoma City, Oklahoma, United States
St Albans, , Australia
Daqing, , China
Dehradun, , India
New Delhi, , India
Khlong Luang, , Thailand
Wiesbaden, , Germany
Taiyuan, , China
Zhuzhou, , China
Ahmedabad, , India
Santiago De Compostela Coruña, , Spain
Yunlin, , Taiwan
Milano, , Italy
Belo Horizonte, , Brazil
Lakeland, Florida, United States
Beavercreek, Ohio, United States
Kraków, , Poland
Adana, , Turkey
San Fernando, , Argentina
Viña Del Mar, , Chile
Jinhua, , China
Lund, , Sweden
Calgary, Alberta, Canada
Caba, , Argentina
Huizhou, , China
Kaifeng, , China
Qingdao, , China
Shaoxing, , China
Shenzhen, , China
Mar Del Plata, , Argentina
Tucumán, , Argentina
Poznań, , Poland
Göteborg, , Sweden
Perth, , United Kingdom
Sao Jose Do Rio Preto, , Brazil
Guri Si, , Korea, Republic Of
Baotou, , China
Biarritz, , France
Bogota, , Colombia
Birtinya, , Australia
Taizhou, , China
Ongkharak, , Thailand
Sibu, , Malaysia
Muang, , Thailand
Gulfport, Mississippi, United States
Mainz, , Germany
Brezno, , Slovakia
Winnipeg, Manitoba, Canada
Aligarh, , India
Piura, , Peru
Las Pinas, , Philippines
Bang Kra So, , Thailand
Orlando, Florida, United States
Exohi Thessaloniki, , Greece
Buford, Georgia, United States
Skórzewo, , Poland
Cabra, , Spain
Zapopan, , Mexico
Quint Fonsegrives, , France
Brasilia, , Brazil
Natal, , Brazil
Oaxaca, , Mexico
Sanya, , China
Merida, , Mexico
Tenerife, , Spain
Jeonju, , Korea, Republic Of
Sun City Center, Florida, United States
Ahmedabad, , India
Chengdu, , China
Benito Juarez, , Mexico
Niterói, , Brazil
Bremen, , Germany
Lawrence Township, New Jersey, United States
Roxas City, , Philippines
Delhi, , India
Marilao, , Philippines
San Miguel De Tucumán, , Argentina
Kobe Shi, , Japan
Peachtree Corners, Georgia, United States
Puerto Princesa City, , Philippines
Cannes, , France
Kajang, , Malaysia
Norfolk, Virginia, United States
Sarawak Miri, , Malaysia
El Agustino, , Peru
Cape Coral, Florida, United States
Weißenburg, , Germany
Salvador, , Brazil
Taoyuan City, , Taiwan
Chęciny, , Poland
Calicut, , India
Uijeongbu, , Korea, Republic Of
Zaozhuang City, , China
Atlanta, Georgia, United States
Monterrey, , Mexico
Gardena, California, United States
Weifang, , China
Hamburg, , Germany
Barcelona, , Spain
Izmir, , Turkey
Paris, Texas, United States
West Valley City, Utah, United States
Long Beach, California, United States
Mullica Hill, New Jersey, United States
Kolkata, , India
Zhangzhou, , China
Tondo, , Philippines
Recife, , Brazil
Union City, New Jersey, United States
Vannes Cedex, , France
Umeå, , Sweden
Campina Grande Do Sul, , Brazil
Essen, , Germany
Solingen, , Germany
Denver, Colorado, United States
Ocala, Florida, United States
Elizabethton, Tennessee, United States
Xi'an, , China
Zigong, , China
Mulhouse, , France
Volta Redonda, , Brazil
Potomac, Maryland, United States
Capital Federal, , Argentina
Fayetteville, North Carolina, United States
Rionegro, , Colombia
Chizhou, , China
Caba, , Argentina
North Hollywood, California, United States
Manadaluyong City, , Philippines
Beijing, , China
Forney, Texas, United States
Wylie, Texas, United States
Vitacura, , Chile
Hyderabad, , India
Wrocław, , Poland
Afyonkarahisar, , Turkey
Mino Shi, , Japan
Kielce, , Poland
Płock, , Poland
Curitiba, , Brazil
Tempe, Arizona, United States
Apple Valley, California, United States
Pomona, California, United States
Vista, California, United States
Denver, Colorado, United States
Downers Grove, Illinois, United States
Lathrup Village, Michigan, United States
Liberty, Missouri, United States
Massapequa, New York, United States
Vestal, New York, United States
North Sioux City, South Dakota, United States
Morristown, Tennessee, United States
Abilene, Texas, United States
Georgetown, Texas, United States
Wichita Falls, Texas, United States
Portsmouth, Virginia, United States
Ciudad Autónomas De Buenos Aires, , Argentina
Serra, , Brazil
Sydney, Nova Scotia, Canada
Thunder Bay, Ontario, Canada
Temuco, , Chile
Victoria, , Chile
Medellin, , Colombia
Vandoeuvre Les Nancy Cedex, , France
Dachau, , Germany
Wallerfing, , Germany
Komádi, , Hungary
Tapolca, , Hungary
Ancona, , Italy
Mestre, , Italy
Perugia, , Italy
Osaka Shi, , Japan
Alor Setar, , Malaysia
Kuala Pilah, , Malaysia
Sandakan, , Malaysia
Metepec, , Mexico
Tijuana, , Mexico
Kongsberg, , Norway
Concepción Del Uruguay, , Peru
Godziesze Małe, , Poland
Libiąż, , Poland
Warszawa, , Poland
Leamna De Sus, , Romania
Targu Mures, , Romania
Badia Del Vallès, , Spain
Castro Urdiales, , Spain
Mataró, , Spain
Palma, , Spain
Viladecans, , Spain
Höllviken, , Sweden
Kungsbacka, , Sweden
Stockholm, , Sweden
Kao Hsiung, , Taiwan
Canakkale, , Turkey
Isparta, , Turkey
Istanbul, , Turkey
Tekirdag, , Turkey
Zeytinburnu, , Turkey
çankaya, , Turkey
Bollington, , United Kingdom
Hownslow, , United Kingdom
North Somerset, , United Kingdom
Nottingham, , United Kingdom
Sheffield, , United Kingdom
Whitney, , United Kingdom
Witney, , United Kingdom
Suining Shi, , China
Wichita, Kansas, United States
Juiz De Fora, , Brazil
Votuporanga, , Brazil
Chongqing, , China
Heze, , China
Shenyang, , China
Taicang, , China
Zhengzhou, , China
Roscoff, , France
Hyderabad, , India
Yamagata Shi, , Japan
Juriquilla, , Mexico
Kráľovský Chlmec, , Slovakia
Topoľčany, , Slovakia
Bicester, , United Kingdom
Fowey, , United Kingdom
Newquay, , United Kingdom
Northallerton, , United Kingdom
Norwich, , United Kingdom
Poole, , United Kingdom
Torbay, , United Kingdom
Mabalacat, , Philippines
Xianyang, , China
Kyiv, , Ukraine
Coffs Harbour, , Australia
Nagpur, , India
Dazhou, , China
Wangaratta, , Australia
Lublin, , Poland
Castroville, California, United States
Taringa, , Australia
Kelowna, British Columbia, Canada
Richmond, British Columbia, Canada
Anyang, , China
Jiaozuo, , China
Piedecuesta, , Colombia
London, , India
Dagupan City, , Philippines
Changhua County, , Taiwan
Chernivtsi, , Ukraine
Chernivtsі, , Ukraine
Sioux City, Iowa, United States
Pierre, South Dakota, United States
Ahrensburg, , Germany
Offenbach Am Main, , Germany
Zhumadian, , China
Cordoba, , Spain
Hefei, , China
Hamilton, Ontario, Canada
Hohhot, , China
Mossoro, , Brazil
Patraix, , Spain
Blois, , France
Dubbo, , Australia
Fortaleza, , Brazil
Passo Fundo, , Brazil
Anning, , China
Qingyuan, , China
Ruian, , China
Shihezi, , China
Xingtai, , China
Cherbourg En Cotentin, , France
Lomme, , France
Vajszló, , Hungary
Pune, , India
Osaki Shi, , Japan
Nis, , Serbia
Bratislava, , Slovakia
Mataro, , Spain
Kungsbacka, , Sweden
Uppsala, , Sweden
Bradford, , United Kingdom
Cardiff, , United Kingdom
Hounslow, , United Kingdom
Sheffield, , United Kingdom
Oradea, , Romania
Waitara, , Australia
Fortaleza, , Brazil
Laval, , France
Negresti Oas, , Romania
Timisoara, , Romania
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported