A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis

Launched by ARGENX · Feb 22, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new medication called empasiprubart to see if it is safe and effective for adults with dermatomyositis, a condition that causes muscle weakness and skin rashes. The trial will last about 92 weeks in total. Participants who qualify will be randomly assigned to receive either empasiprubart or a placebo (a substance with no active medication) for 25 weeks. After this treatment period, all participants will have a follow-up period lasting 65 weeks to monitor their health and safety.

To be eligible for this trial, participants need to be at least 18 years old and have a confirmed diagnosis of dermatomyositis or juvenile dermatomyositis, along with active muscle disease and mild skin symptoms. It's important that participants do not have other serious health issues that could interfere with the study or put them at risk. Throughout the trial, participants will receive regular check-ups and support to ensure their health is closely monitored. If you or a loved one are considering participation, it's a great opportunity to potentially contribute to important research while receiving close medical care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Is at least 18 years of age and the local legal age of consent for clinical studies when signing the Informed Consent Form
• • Is capable of providing signed informed consent and complying with protocol requirements
• • Agrees to use contraceptive measures consistent with local regulations and women of child-bearing potential must have a negative serum pregnancy test at screening and a negative urine pregnancy test before receiving the study drug
• • Has a clinical diagnosis of dermatomyositis or juvenile dermatomyositis. The diagnosis date for juvenile dermatomyositis should be ≤5 years before screening
• • Has active muscle disease associated with classic dermatomyositis or juvenile dermatomyositis at screening and before the first study drug adminisitration and at least 1 of the following: elevated levels of creatine kinase, aldolase, lactate dehydrogenase, aspartate aminotransaminase or alanine aminotransferase at screening; or electromyography ≤18 weeks before the first study drug administration; or an MRI depicting active muscle inflammation ≤18 weeks before the first study drug administration; or muscle biopsy demonstrating signs of active inflammation ≤18 weeks before the first study drug administration
• • Has at least mild skin disease at screening
• • Complies with the permitted background dermatomyositis treatment requirements at screening
• • Has had immunization with the first meningococcal, pneumococcal, and the single Haemophilus influenza type B vaccine ≥14 days before the first study drug administration
• Exclusion Criteria:
• • Known autoimmune disease or any medical condition that would interfere with an accurate assessment of clinical symptoms of dermatomyositis or puts the participant at undue risk
• • Naïve to standard dermatomyositis treatment according to local recommendations
• • History of malignancy unless considered cured by adequate treatment with no evidence of recurrence for ≥3 years before the first study drug administration. Adequately treated participants with the following cancers can be included at any time: Basal cell or squamous cell skin cancer; Carcinoma in situ of the cervix; Carcinoma in situ of the breast; Incidental histological findings of prostate cancer
• • Clinically significant active infection that is not sufficiently resolved before the first study drug administration in the investigator's opinion
• • Positive serum test at screening for active infection with any of the following: Hepatitis B virus, Hepatitis C virus, HIV
• • Clinically significant disease, recent major surgery, or intention to have major surgery during the study; or any other medical condition that, in the investigator's opinion, would confound the results of the study or put the participant at undue risk
• • Current participation in another interventional clinical study
• • Known hypersensitivity to the study drug or any of its excipients
• • History (within 12 months before screening) of or current alcohol, drug, or medication abuse, as assessed by the investigator
• • Pregnant or lactating state or intending to become pregnant during the study
• • Previous participation in an empasiprubart clinical study with at least 1 dose of study drug received
• • Known complement component deficiency as assessed by the investigator
• • Change in dermatomyositis physical therapy or exercise program from ≤4 weeks before screening
• • Inflammatory or non-inflammatory myopathies other than dermatomyositis, such as drug-induced or endocrine-induced myositis, infective myositis, polymyositis, immune-mediated necrotizing myopathy, inclusion body myositis, overlap myositis, metabolic myopathies, or muscle dystrophies
• • Paraneoplastic dermatomyositis secondary to malignancy
• • Glucocorticoid-induced myopathy
• • Severe muscle damage
• • Extensive or severe calcinosis
• • Interstitial lung disease with at least 1 of the following: forced vital capacity (FVC) ≤60%; supplemental oxygen therapy; rapidly progressing uncontrolled interstitial lung disease; moderate or severe interstitial lung disease