Analgesia Nociception Index to Explore Autonomic Nervous System in Patients With Continuous Renal Replacement Therapy

Launched by HOSPICES CIVILS DE LYON · Feb 22, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how the body’s nervous system responds to pain and stress in critically ill patients who are receiving continuous renal replacement therapy (a treatment for kidney failure). Specifically, it looks at a measurement called the Analgesia Nociception Index (ANI), which helps doctors understand the balance of the nervous system during a procedure called net ultrafiltration, where excess fluid is removed from the body. The researchers want to see how changes in the ANI relate to changes in blood pressure and overall health during this treatment.

To participate in this trial, patients must be in an intensive care unit and receiving continuous renal replacement therapy, among other criteria. They should also show signs of fluid overload but not be in critical condition needing extra support from certain medications. If eligible, participants can expect close monitoring while their fluid levels are adjusted, and their nervous system responses will be tracked to gather important information that could help improve future treatments for similar conditions. This study is important because it may provide insights into how to better manage pain and fluid balance in critically ill patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Continuous renal replacement therapy in intensive care unit
• * Initiation of net ultrafiltration according to the protocol of the department or to EARLYDRY study (NCT 05817539) (3 criteria required):
• • Fluid overload \> 5% or peripheral oedema
• • Noradrenaline equivalent \<0.5μg/kg/min
• • No peripheral hypoperfusion
• • Invasive blood pressure monitoring
• • Central venous line in superior vena cava territory
• • Regular sinus rhythm
• • Patient awake or Richmond Agitation and Sedation Scale \> -3
• Exclusion Criteria:
• • Ongoing administration of inotropes
• • Ongoing administration of beta blockers
• • Current administration of alpha-2 agonists
• • History of dysautonomia
• • Pregnant or breast-feeding woman
• • Mechanical circulatory assistance
• • Opposition to participate
• • Adults under legal protection
• • Persons deprived of their liberty by judicial or administrative decision