Glycocalyx Monitoring in Major Abdominal Surgery

Launched by UNIVERSITY HOSPITAL, ROUEN · Feb 22, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how the tiny blood vessels (microcirculation) and a special protective layer around cells (glycocalyx) in the body behave during major abdominal surgeries. By monitoring these factors, the doctors hope to improve how they manage anesthesia and fluid replacement for patients undergoing surgeries like HIPEC (a treatment for certain cancers) and CDP (for pancreatic tumors). This approach aims to provide a more precise and personalized care experience.

To be eligible for this trial, participants need to be adults under 75 years old who are having one of the specific surgeries mentioned. They should also be well-informed about the study and agree to participate. If you join the trial, you can expect to have your microcirculation closely monitored during your surgery, which may help improve your care. However, some patients with serious health issues, like advanced heart or kidney problems, won't be able to participate. It's important to discuss this opportunity with your healthcare team to see if it’s right for you.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• For the HIPEC group :
• • Adult patients
• • Age \< 75 years
• • Receiving HIPEC for primary or secondary peritoneal carcinosis
• For the CDP group :
• • Adult patient
• • Age \< 75 years
• • Receiving CDP for pancreatic neoplasia
• • Patient who has read and understood the information letter and does not object to taking part in the study
• • Patient affiliated to a social security scheme
• Exclusion Criteria:
• • Secondary distant peritoneal metastases
• • Chronic heart failure
• • Chronic liver failure at stage C of the Child-Pugh score
• • Stage IV or V chronic renal failure
• • Inflammation of the sublingual buccal mucosa or injury that may locally influence sublingual microcirculation
• • Patient refusal
• • Person deprived of liberty by an administrative or judicial decision or person placed under court protection or guardianship