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Search / Trial NCT06285708

Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD

Launched by OHIO STATE UNIVERSITY · Feb 22, 2024

Trial Information

Current as of September 08, 2025

Recruiting

Keywords

ClinConnect Summary

This clinical trial is studying how to help individuals who have both post-traumatic stress disorder (PTSD) and suicidal thoughts or behaviors. The researchers want to find out if a combination of two treatment methods—Prolonged Exposure therapy (which helps people face and process their traumatic memories) and a Crisis Response Plan (which provides strategies for managing crises)—is more effective than using Prolonged Exposure therapy alone. The goal is to reduce suicidal thoughts and attempts in people who are seeking help for their PTSD.

To participate in this study, you need to be between 65 and 74 years old and have a diagnosis of PTSD or similar symptoms. You should be able to speak and understand English and give your consent to participate. However, if you have a substance use disorder that needs medical treatment, are at immediate risk of suicide, or have serious issues that affect your ability to understand the study, you won’t be eligible. If you join the trial, you can expect to receive support through these therapies and contribute to important research that could help others in similar situations.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Current diagnosis of PTSD or subthreshold PTSD; ability to speak and understand the English language; and ability to complete the informed consent process.
  • Exclusion Criteria:
  • Substance use disorder requiring medical management; imminent suicide risk warranting inpatient hospitalization or suicide-focused treatment; and impaired mental status that precludes the ability to provide informed consent (e.g., intoxication, psychosis, mania).

About Ohio State University

The Ohio State University (OSU) is a leading research institution dedicated to advancing health and science through innovative clinical trials. With a commitment to improving patient care and outcomes, OSU leverages its extensive resources, interdisciplinary collaboration, and expertise in diverse medical fields. The university fosters an environment of rigorous scientific inquiry, ensuring that clinical trials are conducted with the highest ethical standards and adherence to regulatory guidelines. Through its Clinical Trials Office, OSU aims to translate groundbreaking research into practical applications, benefiting both local and global communities.

Locations

Columbus, Ohio, United States

Patients applied

0 patients applied

Trial Officials

Jaryd Hiser, Ph.D.

Principal Investigator

Assistant Professor

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported