Alpha Lipoic Acid in Pediatrics on Hemodialysis
Launched by AIN SHAMS UNIVERSITY · Feb 23, 2024
Trial Information
Current as of July 22, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
A Double-Blinded, Paralleled, Randomized, Placebo-Controlled Clinical Trial will be conducted at the Pediatric Nephrology and Dialysis Unit, Children's Hospital, Ain Shams University, Cairo, Egypt to detect the efficacy of alpha lipoic acid in reducing cardiovascular events by reducing oxidative stress-mediated endothelial dysfunction in pediatric population on regular hemodialysis by assessment of:
1. E-selectin as an Endothelial biomarker
2. SOD as an Oxidative stress biomarker
3. Indicators of CVS dysfunction by;
* Duplex ultrasonography
* Echocardiogram with stress on Ejection F...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Pediatric participants admitted to Pediatric Hemodialysis Unit for regular hemodialysis.
- • The ability to swallow capsules will be enrolled in the study.
- Exclusion Criteria:
- • Participants who suffered from severe congestive heart failure
- • Participants suffering from inflammatory diseases or other diseases that may increase oxidative stress.
- • Participants taking supplements that decrease oxidative stress or inflammatory markers
- • Participants with hypersensitivity to alpha lipoic acid
- • Participants who are non-compliant.
About Ain Shams University
Ain Shams University, established in Cairo, Egypt, is a prestigious higher education institution renowned for its commitment to academic excellence and research innovation. As a clinical trial sponsor, the university leverages its extensive resources and expertise in various medical and scientific disciplines to advance healthcare through rigorous research initiatives. With a focus on ethical practices and adherence to regulatory standards, Ain Shams University aims to contribute to the development of new therapies and improve patient outcomes, fostering collaboration among researchers, healthcare professionals, and industry partners in the pursuit of medical advancements.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cairo, El Weili, Egypt
Patients applied
Trial Officials
Mahmoud Mohsen, Pharmacist
Principal Investigator
Misr University for Science and Technology
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported