Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients

Launched by IMPERIAL COLLEGE LONDON · Feb 22, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating the causes of chronic cough, which is a cough that lasts more than 8 weeks. Researchers want to understand if inflammation in the lungs is linked to this condition and whether a chemical in the body called adenosine triphosphate (ATP) might be contributing to it. To do this, they will compare 10 individuals with chronic cough to 8 healthy individuals who do not have a cough.

If you are between 30 and 70 years old and have been experiencing a chronic cough for at least 8 weeks, you might be eligible to participate. Healthy individuals without significant health issues are also welcome to join. Participants will undergo tests to help researchers learn more about the differences between those with and without chronic cough. It's important to note that all participants will need to give their consent and be able to understand the study procedures. This research could provide valuable insights into better understanding and treating chronic cough in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - 1. For Normal non-smoking subject: Healthy individuals, free of significant disease No history of asthma/rhinitis, No therapies, Baseline FEV1 ≥80% predicted with FEV1/FVC ratio \>70% Non-smoker for at least the past 12 months with a pack history of ≤5 pack-years
• • 2. For chronic cough participants: History of chronic cough of at least 8 weeks' duration and should have been followed in the Cough Clinic for at least 6 months.
• • Undergone a protocol with a diagnostic pathway as recommended by the ERS guidelines for management of cough.
• • Would have either an identifiable cause for their cough that have failed therapies targeted towards the identified cause or classed as having chronic idiopathic cough where no identifiable cause has been found.
• • 3. General Inclusion Criteria: Give written informed consent prior to participation in the study including all of its procedures. Comply with the requirements and restrictions listed in the consent form.
• • Male or female subject aged between 30 and 70 years old at screening. Able to complete the study and all measurements. Able to read, comprehend, and write at a sufficient level to complete study related materials.
• Exclusion Criteria:
• • -