Pelvic Neuro-Angiogenesis in Deep Endometriosis

Launched by ULUDAG UNIVERSITY · Feb 22, 2024

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how deep endometriosis affects nerve and blood vessel growth in the pelvic area. Endometriosis is a condition that affects many women, causing tissue similar to the lining of the uterus to grow outside of its normal place, which can lead to pain and other symptoms. The researchers want to find out how changes in the tissue around endometriotic nodules—specifically the nerve and blood vessel density—can contribute to pain and discomfort. This information may help doctors decide how much tissue needs to be removed during surgery to effectively relieve symptoms.

Women aged 18 to 45 who have been diagnosed with deep endometriosis, haven't found relief with medication, and are planning to undergo a specific type of surgery (called laparoscopic conservative endometriosis surgery) may be eligible to participate. During the trial, participants will have tissue samples taken during their surgery to study the nerve and blood vessel structures. This research aims to improve surgical outcomes and better understand how endometriosis affects women's health, even in areas that may look healthy at first glance.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Patients with suspicion of deep endometriosis (Physical Examination and MRI)
• • Patients with ineffective response to medical therapy
• • Patients who undergo laparoscopic conservative endometriosis surgery (douglasectomy)
• Exclusion Criteria:
• • Patients with malignity suspicion
• • Patients with extensive surgery (hysterectomy, ovariectomy)
• • Patients with previous endometriosis or another pelvic surgery
• • Patients with oocyte pick up procedure history
• • Patients with pelvic inflammatory disease history